3,5-dimethylpyridine-4-carboxylic acid

Base Information

• Chemical Name: 3,5-dimethylpyridine-4-carboxylic acid
• CAS No.: 544703-96-0
• Molecular Formula: C₈H₉NO₂
• Molecular Weight: 151.165
• Hs Code.: 2933399090
• Mol file: 544703-96-0.mol

Synonyms:3,5-dimethylpyridine-4-carboxylic acid;4-Pyridinecarboxylicacid,3,5-dimethyl-(9CI);3,5-Dimethylisonicotinic acid

Chemical Property of 3,5-dimethylpyridine-4-carboxylic acid

Chemical Property:

• Vapor Pressure: 1.04E-06mmHg at 25°C
• Refractive Index: 1.553
• Boiling Point: 387.9oC at 760 mmHg
• PKA: 0.48±0.37(Predicted)
• Flash Point: 188.4oC
• PSA: 50.19000
• Density: 1.183g/cm3
• LogP: 1.39660
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3,5-DimethylisonicotinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-dimethylpyridine-4-carboxylic acid

There total 5 articles about 3,5-dimethylpyridine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

3,5-dimethylpyridine-4-carbonitrile (7584-08-9) → 2,6-dimethylisonicotinic acid (544703-96-0)

Guidance literature:

With hydrogenchloride; at 165 ℃;

DOI:10.1016/S0960-894X(02)00918-6

Reference yield:

3,5-Lutidine (591-22-0) → 2,6-dimethylisonicotinic acid (544703-96-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: NH₂SO₃K; HI; K₂CO₃

2.2: Amberlite resin; 10 percent aq. NaOH

3.1: 66 percent / conc. aq. HCL / 165 °C

With hydrogenchloride; potassium sulfamate; hydrogen iodide; potassium carbonate;

DOI:10.1016/S0960-894X(02)01063-6

Reference yield:

1-Acetimino-3,5-dimethyl-pyridin (7584-31-8) → 2,6-dimethylisonicotinic acid (544703-96-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 66 percent / conc. aq. HCL / 165 °C

With hydrogenchloride;

DOI:10.1016/S0960-894X(02)01063-6

upstream raw materials:

3,5-dimethylpyridine-4-carbonitrile

3,5-Lutidine

1-Acetimino-3,5-dimethyl-pyridin

3,5-dimethyl-N-aminopyridinium iodide