(3R,5S)-5-[(tert-Butyloxycarbonylamino)methyl]pyrrolidine-3-ol

Base Information

Chemical Name:(3R,5S)-5-[(tert-Butyloxycarbonylamino)methyl]pyrrolidine-3-ol
CAS No.:500733-24-4
Molecular Formula:C10H20N2O3
Molecular Weight:216.2774
Hs Code.:
European Community (EC) Number:872-223-9
Nikkaji Number:J2.286.936A
Mol file:500733-24-4.mol

Synonyms:500733-24-4;(3R,5S)-5-[(tert-Butyloxycarbonylamino)methyl]pyrrolidine-3-ol;tert-butyl N-[[(2S,4R)-4-hydroxypyrrolidin-2-yl]methyl]carbamate;tert-Butyl N-{[(2S,4R)-4-hydroxypyrrolidin-2-yl]methyl}carbamate;EN300-7139727;tert-ButylN-{[(2S,4R)-4-hydroxypyrrolidin-2-yl]methyl}carbamate

Suppliers and Price of (3R,5S)-5-[(tert-Butyloxycarbonylamino)methyl]pyrrolidine-3-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
(3R,5S)-5-[(Tert-Butyloxycarbonylamino)methyl]pyrrolidine-3-ol
2.5g
$ 1837.00

Total 2 raw suppliers

Chemical Property of (3R,5S)-5-[(tert-Butyloxycarbonylamino)methyl]pyrrolidine-3-ol

Chemical Property:

XLogP3:0.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:216.14739250
Heavy Atom Count:15
Complexity:225

Purity/Quality:

97% ^*data from raw suppliers

(3R,5S)-5-[(Tert-Butyloxycarbonylamino)methyl]pyrrolidine-3-ol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NCC1CC(CN1)O
Isomeric SMILES:CC(C)(C)OC(=O)NC[C@@H]1C[C@H](CN1)O

Technology Process of (3R,5S)-5-[(tert-Butyloxycarbonylamino)methyl]pyrrolidine-3-ol

There total 8 articles about (3R,5S)-5-[(tert-Butyloxycarbonylamino)methyl]pyrrolidine-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 847994-36-9
(2S,4R)-N₁-(benzyloxycarbonyl)-2-(tert-butyloxycarbonylaminomethyl)-4-hydroxy-pyrrolidine

: 500733-24-4,336192-13-3
(2S,4R)-2-(tert-butyloxycarbonylaminomethyl)-4-hydroxypyrrolidine

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 7h; under 3102.97 Torr;
DOI:10.1039/b413542c

Reference yield:

: 64187-48-0
methyl (2S,4R)-1-benzyloxycarbonyl-4-hydroxypyrrolidine-2-carboxylate

: 500733-24-4,336192-13-3
(2S,4R)-2-(tert-butyloxycarbonylaminomethyl)-4-hydroxypyrrolidine

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / LiCl; NaBH₄ / tetrahydrofuran; ethanol / 20 °C

2: 75 percent / pyridine / 8 h / 20 °C

3: 96 percent / NaN₃ / dimethylformamide / 8 h / 55 °C

4: H₂ / Raney Ni / methanol / 3.5 h / 20 °C / 1810.02 - 2068.59 Torr

5: 76 percent / Et₃N / dimethylsulfoxide / 8 h / 50 °C

6: H₂ / Pd/C / methanol / 7 h / 20 °C / 3102.89 Torr

With pyridine; sodium tetrahydroborate; sodium azide; hydrogen; triethylamine; lithium chloride; palladium on activated charcoal; nickel; In tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2005.12.002

Reference yield:

: 95687-41-5,1448706-36-2
(2S,4R)-N1-(benzyloxycarbonyl)-4-hydroxy-2-(hydroxymethyl)-pyrrolidine

: 500733-24-4,336192-13-3
(2S,4R)-2-(tert-butyloxycarbonylaminomethyl)-4-hydroxypyrrolidine

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / pyridine / 8 h / 20 °C

2: 96 percent / NaN₃ / dimethylformamide / 8 h / 55 °C

3: H₂ / Raney Ni / methanol / 3.5 h / 20 °C / 1810.02 - 2068.59 Torr

4: 76 percent / Et₃N / dimethylsulfoxide / 8 h / 50 °C

5: H₂ / Pd/C / methanol / 7 h / 20 °C / 3102.89 Torr

With pyridine; sodium azide; hydrogen; triethylamine; palladium on activated charcoal; nickel; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2005.12.002