(S)-N1-((1H-Benzo[d]imidazol-2-yl)methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine

Base Information

Chemical Name:(S)-N1-((1H-Benzo[d]imidazol-2-yl)methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine
CAS No.:558447-26-0
Deprecated CAS:690656-53-2
Molecular Formula:C21H27N5
Molecular Weight:349.479
Hs Code.:2933990090
UNII:0G9LGB5O2W
ChEMBL ID:CHEMBL518924
DSSTox Substance ID:DTXSID60971247
Metabolomics Workbench ID:149498
NCI Thesaurus Code:C126660
Nikkaji Number:J2.798.825C
Pharos Ligand ID:9KBCS5NQJAPG
Wikidata:Q27074430
Mol file:558447-26-0.mol

Synonyms:AMD 070;AMD 11070;AMD-070;AMD-11070;AMD070;AMD11070;mavorixafor;N'-((1H-benzo(d)imidazol-2-yl)methyl)-N'-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine;X 4P-001;X4P-001;X4P001

Suppliers and Price of (S)-N1-((1H-Benzo[d]imidazol-2-yl)methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-(1H-Benzimidazol-2-ylmethyl)-N-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-1,4-butanediamine
25mg
$ 475.00

DC Chemicals
Mavorixafor(AMD-070) >98%
1g
$ 2400.00

DC Chemicals
Mavorixafor(AMD-070) >98%
250mg
$ 1200.00

DC Chemicals
Mavorixafor(AMD-070) >98%
100mg
$ 700.00

Crysdot
AMD-070 98+%
50mg
$ 586.00

Crysdot
AMD-070 98+%
10mg
$ 196.00

Crysdot
AMD-070 98+%
100mg
$ 911.00

Crysdot
AMD-070 98+%
5mg
$ 112.00

Chemenu
(S)-N1-((1H-Benzo[d]imidazol-2-yl)methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine 97%
1g
$ 3037.00

Cayman Chemical
Mavorixafor
5mg
$ 103.00

Total 25 raw suppliers

Chemical Property of (S)-N1-((1H-Benzo[d]imidazol-2-yl)methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine

Chemical Property:

Melting Point:108-110℃
Boiling Point:597.0±50.0 °C(Predicted)
PKA:11.65±0.10(Predicted)
PSA：70.83000
Density:1.21
LogP:4.27670
Solubility.:≥17.45 mg/mL in DMSO; ≥44.5 mg/mL in EtOH; ≥7.47 mg/mL in H2O with gentle warming
XLogP3:2.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:349.22664588
Heavy Atom Count:26
Complexity:431

Purity/Quality:

99%, ^*data from raw suppliers

N-(1H-Benzimidazol-2-ylmethyl)-N-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-1,4-butanediamine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(C2=C(C1)C=CC=N2)N(CCCCN)CC3=NC4=CC=CC=C4N3
Isomeric SMILES:C1C[C@@H](C2=C(C1)C=CC=N2)N(CCCCN)CC3=NC4=CC=CC=C4N3
Recent ClinicalTrials:A Study of Mavorixafor in Participants With Congenital and Acquired Primary Autoimmune and Idiopathic Chronic Neutropenic Disorders Who Are Experiencing Recurrent and/or Serious Infections
Recent EU Clinical Trials:A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of Mavorixafor in Patients with WHIM Syndrome with Open-Label Extension

Technology Process of (S)-N1-((1H-Benzo[d]imidazol-2-yl)methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine

There total 11 articles about (S)-N1-((1H-Benzo[d]imidazol-2-yl)methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1044264-94-9
C₃₄H₃₇N₅O₄

: 558447-26-0
AMD₀₇₀

Guidance literature:: With hydrazine; In ethanol; for 3h;

Reference yield: 78.0%

: 865202-97-7
C₃₆H₅₁N₅O₆

: 558447-26-0
AMD₀₇₀

Guidance literature:: C₃₆H₅₁N₅O₆; With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 20h; pH=2;

With sodium hydroxide; In tetrahydrofuran; water; at 0 ℃; pH=6; Product distribution / selectivity;