Cyclopentanecarboxylic acid, 2-(hydroxymethyl)-, methyl ester, (1R,2R)-rel-

Base Information

• Chemical Name: Cyclopentanecarboxylic acid, 2-(hydroxymethyl)-, methyl ester, (1R,2R)-rel-
• CAS No.: 502650-66-0
• Molecular Formula: C₈H₁₄O₃
• Molecular Weight: 158.197
• Hs Code.: 2918199090
• Mol file: 502650-66-0.mol

Synonyms:Cyclopentanecarboxylic acid, 2-(hydroxymethyl)-, methyl ester, (1R,2R)-rel-

Chemical Property of Cyclopentanecarboxylic acid, 2-(hydroxymethyl)-, methyl ester, (1R,2R)-rel-

Chemical Property:

• Vapor Pressure: 0.0129mmHg at 25°C
• Refractive Index: 1.467
• Boiling Point: 230°C at 760 mmHg
• Flash Point: 91.5°C
• PSA: 46.53000
• Density: 1.091g/cm³
• LogP: 0.56800

Purity/Quality:

98%Min ^*data from raw suppliers

Methyltrans-2-Hydroxymethylcyclopentane-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclopentanecarboxylic acid, 2-(hydroxymethyl)-, methyl ester, (1R,2R)-rel-

There total 2 articles about Cyclopentanecarboxylic acid, 2-(hydroxymethyl)-, methyl ester, (1R,2R)-rel- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

trans-cyclopentane-1,2-dicarboxylic acid monomethyl ester → 2-hydroxymethyl-cyclopentanecarboxylic acid methyl ester (502650-66-0)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; at -20 - 20 ℃; for 12h;

DOI:10.1055/s-2004-835669

Reference yield:

cis-2-carbomethoxy cyclopentane-1-carboxylic acid → 2-hydroxymethyl-cyclopentanecarboxylic acid methyl ester (502650-66-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / t-BuOK / tetrahydrofuran / 1 h / 0 - 20 °C

2: 60 percent / BH₃*SMe₂ / tetrahydrofuran / 12 h / -20 - 20 °C

With dimethylsulfide borane complex; potassium tert-butylate; In tetrahydrofuran;

DOI:10.1055/s-2004-835669

Refernces