6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLIC ACID, METHYL ESTER

Base Information

• Chemical Name: 6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLIC ACID, METHYL ESTER
• CAS No.: 572910-59-9
• Molecular Formula: C₈H₆ClN₃O₂
• Molecular Weight: 211.608
• Hs Code.: 2933990090
• Mol file: 572910-59-9.mol

Synonyms:6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLIC ACID, METHYL ESTER

Chemical Property of 6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLIC ACID, METHYL ESTER

Chemical Property:

• Refractive Index: 1.668
• PKA: 0.09±0.30(Predicted)
• PSA: 56.49000
• Density: 1.54g/cm³
• LogP: 1.16930
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

6-Chloro-imidazo[1,2-b]pyridazine-2-carboxylicacidmethylester >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLIC ACID, METHYL ESTER

There total 1 articles about 6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLIC ACID, METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.66%

6-chloro-pyridazin-3-ylamine (5469-69-2) + methyl 3-bromo-2-oxopropanoate (7425-63-0) → methyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate (572910-59-9)

Guidance literature:

In N,N-dimethyl acetamide; at 50 ℃; for 1.5h; Inert atmosphere;

Reference yield: 29.43%

methyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate (572910-59-9) + Trimethylacetic acid (75-98-9) → methyl 8-tert-butyl-6-chloroimidazo[1,2-b]pyridazine-2-carboxylate (1690176-75-0)

Guidance literature:

With silver nitrate; trifluoroacetic acid; In water; acetonitrile; at 80 ℃; for 1h; Inert atmosphere;

Reference yield:

methyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate (572910-59-9) → 1-[8-tert-butyl-6-(4-fluorophenyl)imidazo[1,2-b]pyridazine-2-carbonyl]-2,2-dimethylpiperidin-4-one

Guidance literature:

Multi-step reaction with 4 steps

1: trifluoroacetic acid; silver nitrate / water; acetonitrile / 1 h / 80 °C / Inert atmosphere

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / N,N-dimethyl-formamide / 18 h / 80 °C / Inert atmosphere

3: sodium hydroxide / methanol / 2 h / 20 °C

4: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; silver nitrate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In methanol; water; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

6-chloro-pyridazin-3-ylamine

methyl 3-bromo-2-oxopropanoate

Downstream raw materials:

methyl 8-tert-butyl-6-chloroimidazo[1,2-b]pyridazine-2-carboxylate