6-(2-Fluorophenyl)-nicotinic acid

Base Information

• Chemical Name: 6-(2-Fluorophenyl)-nicotinic acid
• CAS No.: 505082-91-7
• Molecular Formula: C12H8FNO2
• Molecular Weight: 217.199
• Hs Code.: 2933399090
• Mol file: 505082-91-7.mol

Synonyms:6-(2-fluorophenyl)-pyridine-3-carboxylic acid;6-(2-Fluorophenyl)nicotinic acid;

Chemical Property of 6-(2-Fluorophenyl)-nicotinic acid

Chemical Property:

• PSA: 50.19000
• LogP: 2.58590
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

6-(2-Fluorophenyl)nicotinic acid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-(2-Fluorophenyl)-nicotinic acid

There total 3 articles about 6-(2-Fluorophenyl)-nicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

tert-butyl 6-(2-fluorophenyl)nicotinate (1033844-92-6) → 6-(2-fluorophenyl)pyridine-3-carboxylic acid (505082-91-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃;

Reference yield: 90.0%

6-bromonicotinic acid (6311-35-9) + o-fluorophenylboronic acid (1993-03-9) → 6-(2-fluorophenyl)pyridine-3-carboxylic acid (505082-91-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; at 100 ℃; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.jmedchem.9b01218

Reference yield:

C13H10FNO2 → 6-(2-fluorophenyl)pyridine-3-carboxylic acid (505082-91-7)

Guidance literature:

With lithium hydroxide; water; In 1,4-dioxane; at 20 ℃;

DOI:10.1016/j.bmcl.2008.08.105

upstream raw materials:

tert-butyl 6-(2-fluorophenyl)nicotinate

6-bromonicotinic acid

o-fluorophenylboronic acid

Downstream raw materials:

6-(2-fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]nicotinamide

C₂₁H₁₄FN₃O

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