4-Iodo-2,6-pyridinedicarboxaldehyde

Base Information

• Chemical Name: 4-Iodo-2,6-pyridinedicarboxaldehyde
• CAS No.: 506423-88-7
• Molecular Formula: C7H4INO2
• Molecular Weight: 261.02
• Hs Code.: 2933399090
• Mol file: 506423-88-7.mol

Synonyms:4-Iodo-2,6-pyridinedicarboxaldehyde

Chemical Property of 4-Iodo-2,6-pyridinedicarboxaldehyde

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.723
• Boiling Point: 326.491°C at 760 mmHg
• PKA: -0.06±0.10(Predicted)
• Flash Point: 151.257°C
• PSA: 47.03000
• Density: 2.038g/cm³
• LogP: 1.31120

Purity/Quality:

99% ^*data from raw suppliers

4-IODO-2,6-PYRIDINEDICARBOXALDEHYDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Iodo-2,6-pyridinedicarboxaldehyde

There total 4 articles about 4-Iodo-2,6-pyridinedicarboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,6-bis(hydroxymethyl)-4-iodopyridine (120491-91-0) → 4-iodopyridine-2,6-dicarbaldehyde (506423-88-7)

Guidance literature:

With selenium(IV) oxide; In 1,4-dioxane; for 5.5h; Heating;

DOI:10.1002/1099-0690(200211)2002:21<3680::AID-EJOC3680>3.0.CO;2-4

Reference yield:

4-iodo-pyridine-2,6-dicarboxylic acid (506423-80-9) → 4-iodopyridine-2,6-dicarbaldehyde (506423-88-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / sulfuric acid / 4 h / Heating

2: 70 percent / sodium borohydride / methanol / 17 h / Heating

3: 90 percent / selenium dioxide / dioxane / 5.5 h / Heating

With sodium tetrahydroborate; selenium(IV) oxide; sulfuric acid; In 1,4-dioxane; methanol;

DOI:10.1002/1099-0690(200211)2002:21<3680::AID-EJOC3680>3.0.CO;2-4

Reference yield:

dimethyl 4-chloro-2,6-pyridinedicarboxylate (5371-70-0) → 4-iodopyridine-2,6-dicarbaldehyde (506423-88-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / hydrogen iodide; phosphorous acid / 5 h / Heating

2: 70 percent / sulfuric acid / 4 h / Heating

3: 70 percent / sodium borohydride / methanol / 17 h / Heating

4: 90 percent / selenium dioxide / dioxane / 5.5 h / Heating

With sodium tetrahydroborate; selenium(IV) oxide; phosphonic Acid; sulfuric acid; hydrogen iodide; In 1,4-dioxane; methanol;

DOI:10.1002/1099-0690(200211)2002:21<3680::AID-EJOC3680>3.0.CO;2-4

upstream raw materials:

2,6-bis(hydroxymethyl)-4-iodopyridine

4-iodo-pyridine-2,6-dicarboxylic acid

dimethyl 4-chloro-2,6-pyridinedicarboxylate

4-iodo-2,6-pyridinedicarboxylic acid dimethyl ester