(4R)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-hydroxypentanoic acid ethyl ester

Base Information

• Chemical Name: (4R)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-hydroxypentanoic acid ethyl ester
• CAS No.: 597577-78-1
• Molecular Formula: C12H23NO5
• Molecular Weight: 261.31472
• Mol file: 597577-78-1.mol

Synonyms:(4R)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-hydroxypentanoic acid ethyl ester

Chemical Property of (4R)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-hydroxypentanoic acid ethyl ester

Chemical Property:

• PSA: 88.35000
• LogP: 1.41970

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4R)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-hydroxypentanoic acid ethyl ester

There total 4 articles about (4R)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-hydroxypentanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(R)-2-Boc-aminopentanoic acid 5-ethyl ester-1-methyl ester → (4R)-4-t-butoxycarbonylamino-5-hydroxypentanoic acid ethyl ester (597577-78-1)

Guidance literature:

With methanol; lithium borohydride; In tetrahydrofuran; at 10 ℃; for 2h;

Reference yield: 75.0%

(R)-2-BOC-amino-pentanoic acid 5-ethylester-1-methyl ester → (4R)-4-t-butoxycarbonylamino-5-hydroxypentanoic acid ethyl ester (597577-78-1)

Guidance literature:

(R)-2-BOC-amino-pentanoic acid 5-ethylester-1-methyl ester; With lithium borohydride; In tetrahydrofuran; methanol; at 10 ℃; for 2h;

With water; In tetrahydrofuran; methanol; at 0 ℃;

Reference yield: 66.0%

C16H24N2O8 (1355026-75-3) → (4R)-4-t-butoxycarbonylamino-5-hydroxypentanoic acid ethyl ester (597577-78-1)

Guidance literature:

With lithium borohydride; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2011.10.109

upstream raw materials:

N-Boc-D-glutamic acid γ-ethyl ester

C₁₆H₂₄N₂O₈