1-Methyl-2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylic acid

Base Information

• Chemical Name: 1-Methyl-2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylic acid
• CAS No.: 14271-45-5
• Molecular Formula: C₁₁H₁₁NO₃
• Molecular Weight: 205.213
• Hs Code.: 2933790090
• European Community (EC) Number: 874-323-8
• DSSTox Substance ID: DTXSID20585425
• Mol file: 14271-45-5.mol

Synonyms:14271-45-5;1-methyl-2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylic acid;1-methyl-2-oxo-3,4-dihydroquinoline-4-carboxylic acid;1-methyl-2-oxo-1,2,3,4-tetrahydro-4-quinolinecarboxylic acid;1-METHYL-2-OXO-1,2,3,4-TETRAHYDROQUINOLINE-4-CARBOXYLICACID;DTXSID20585425;MFCD08691279;AKOS000119252;AKOS016042113;BS-37265;EN300-26297;G21978;Z221583702

Chemical Property of 1-Methyl-2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylic acid

Chemical Property:

• PSA: 57.61000
• LogP: 1.28630
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly), Ethyl Acetate (Slight
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 205.07389321
• Heavy Atom Count: 15
• Complexity: 290

Purity/Quality:

98%Min ^*data from raw suppliers

1-Methyl-2-oxo-3,4-dihydroquinoline-4-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1C(=O)CC(C2=CC=CC=C21)C(=O)O
• Uses: 1-Methyl-2-oxo-3,4-dihydroquinoline-4-carboxylic Acid preparation of heterocyclyl indanylamides as modulators of mGluR7 useful in mono- or combination therapy of diseases.

Technology Process of 1-Methyl-2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylic acid

There total 4 articles about 1-Methyl-2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 1-methyl-2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylic acid (14271-45-5)

Guidance literature:

With sodium amalgam; alkaline solution;

Reference yield:

2-quinolone-4-carboxylic acid (15733-89-8) → 1-methyl-2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylic acid (14271-45-5)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminium amalgam

2: NaOH-solution / nachfolgend Erhitzen mit Natronlauge

With sodium hydroxide; aluminium amalgam;

Reference yield:

2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylic acid (14179-84-1) + dimethyl sulfate (77-78-1) → 1-methyl-2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylic acid (14271-45-5)

Guidance literature:

With sodium hydroxide; nachfolgend Erhitzen mit Natronlauge;

upstream raw materials:

2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylic acid

dimethyl sulfate

2-quinolone-4-carboxylic acid