Cyclohexaneacetonitrile, 1-fluoro--alpha--hydroxy-

Base Information

• Chemical Name: Cyclohexaneacetonitrile, 1-fluoro--alpha--hydroxy-
• CAS No.: 699-43-4
• Molecular Formula: C8H12FNO
• Molecular Weight: 157.188
• Hs Code.: 2926909090
• Mol file: 699-43-4.mol

Synonyms:Cyclohexaneacetonitrile, 1-fluoro--alpha--hydroxy-

Chemical Property of Cyclohexaneacetonitrile, 1-fluoro--alpha--hydroxy-

Chemical Property:

• PSA: 44.02000
• LogP: 1.54328

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclohexaneacetonitrile, 1-fluoro--alpha--hydroxy-

There total 5 articles about Cyclohexaneacetonitrile, 1-fluoro--alpha--hydroxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-oxaspiro<2,5>octane-2-carboxylic acid nitrile (36929-66-5,500899-63-8,500899-64-9) → α-(1-Fluorocyclohexyl)-α-hydroxyacetonitrile (699-43-4)

Guidance literature:

With pyridine; hydrogen fluoride; In dichloromethane; at 25 ℃; for 3h;

DOI:10.1016/S0022-1139(00)82265-4

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → α-(1-Fluorocyclohexyl)-α-hydroxyacetonitrile (699-43-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / t-BuOK / 2-methyl-propan-2-ol / Ambient temperature

2: 86 percent / 70percent HF / CH₂Cl₂; pyridine / 1.) 0 deg C, 1 h, 2.) room temp., 1 h

With hydrogen fluoride; potassium tert-butylate; In pyridine; dichloromethane; tert-butyl alcohol;

DOI:10.1055/s-1988-27551

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → α-(1-Fluorocyclohexyl)-α-hydroxyacetonitrile (699-43-4)

Guidance literature:

Multi-step reaction with 2 steps

1: t-BuOK / 2-methyl-propan-2-ol

2: 88 percent / HF/pyridine / CH₂Cl₂ / 2 h

With pyridine; hydrogen fluoride; potassium tert-butylate; In dichloromethane; tert-butyl alcohol;

DOI:10.1016/S0040-4039(01)90362-4

upstream raw materials:

1-oxaspiro<2,5>octane-2-carboxylic acid nitrile

cyclohexanone

Downstream raw materials:

2-amino-2-(1-fluorocyclohexyl)ethanonitrile

1-Fluoro-1-hydroxymethylcyclohexane

2-(1-fluorocyclohexyl)-2-ketoethanoic acid

<(5E,Z),(13E)>-15-(1-Fluorocyclohexyl)-11α,(15R)-dihydroxy-ω-pentanor-9a-carbaprostacyclin

Refernces

• 1、 Ayi, A. I.,Remli, M.,Condom, R.,Guedj, R.. "NEW SYNTHETIC ROUTES TO β-FLUORO β-PHENYLLACTIC ACID DERIVATIVES AND Β-FLUOROCYANOHYDRINS". . p. 565 - 580. Retrieved 2007/10/02.
• 2、 Ayi, A. I.,Remli, M.,Guedj, R.. "NEW SYNTHETIC ROUTES TO β-FLUORO-α-AMINOACIDS B - FROM GLYCIDONITRILES". . p. 540 - 541. Retrieved 2007/10/02.