(2S,4S)-4-Methylglutamic acid

Base Information

Chemical Name:(2S,4S)-4-Methylglutamic acid
CAS No.:6141-27-1
Molecular Formula:C6H11NO4
Molecular Weight:161.158
Hs Code.:2922499990
UNII:NPW4ZK5UGA,G44Q8UU4V9
DSSTox Substance ID:DTXSID70390561
Nikkaji Number:J686.917C
Wikidata:Q82187421
ChEMBL ID:CHEMBL41221
Mol file:6141-27-1.mol

Synonyms:6141-27-1;(2S,4S)-4-METHYLGLUTAMIC ACID;(2S,4S)-2-amino-4-methylpentanedioic acid;(4S)-4-Methyl-L-glutamic Acid;NPW4ZK5UGA;CHEMBL41221;2S,4S-4-Methylglutamic acid;G44Q8UU4V9;4-Methyl-DL-glutamic acid, threo-;4-Methyl-L-glutamic acid, (4S)-;DL-Glutamic acid, 4-methyl-, threo-;L-Glutamic acid, 4-methyl-, (4S)-;D-Glutamic acid, 4-methyl-, (4R)-rel-;38523-28-3;NSC-41355;starbld0018205;UNII-NPW4ZK5UGA;NCIStruc1_000060;NCIStruc2_000006;UNII-G44Q8UU4V9;SCHEMBL2263577;DTXSID70390561;NCI41355;BDBM50031703;CCG-36834;NCGC00013482;AKOS006275456;NCGC00013482-02;NCGC00013482-03;NCGC00096596-01;NCGC00096596-02;(2S,4S)-2-Amino-4-methyl-pentanedioic acid;2-Amino-4-methyl-pentanedioic acid(S-Me-Glu)

Suppliers and Price of (2S,4S)-4-Methylglutamic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2S,4S)-4-MethylglutamicAcid
10mg
$ 250.00

Medical Isotopes, Inc.
(2S,4S)-4-MethylglutamicAcid
25 mg
$ 2000.00

American Custom Chemicals Corporation
(2S,4S)-4-METHYLGLUTAMIC ACID 95.00%
50MG
$ 1732.50

American Custom Chemicals Corporation
(2S,4S)-4-METHYLGLUTAMIC ACID 95.00%
5MG
$ 756.25

Total 9 raw suppliers

Chemical Property of (2S,4S)-4-Methylglutamic acid

Chemical Property:

PSA：100.62000
LogP:0.20940
Storage Temp.:-20°C Freezer
Solubility.:Methanol (Slightly), Water (Soluble)
XLogP3:-2.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:161.06880783
Heavy Atom Count:11
Complexity:168

Purity/Quality:

97% ^*data from raw suppliers

(2S,4S)-4-MethylglutamicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(CC(C(=O)O)N)C(=O)O
Isomeric SMILES:C[C@@H](C[C@@H](C(=O)O)N)C(=O)O
Uses A highly selective and potent agonist for metabotropic receptors (2S,4S)-4-Methylglutamic Acid is a potent and selective kainate receptor agonist (1). It has been shown that (2S,4S)-4-Methylglutamic Acid can desensitize kainate receptors and also attenuate capsaicin and inflammatory hyperalgesia (2).

Technology Process of (2S,4S)-4-Methylglutamic acid

There total 29 articles about (2S,4S)-4-Methylglutamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1030836-20-4
dimethyl (2S,4S)-N-(tert-butoxycarbonyl)-4-methylglutamate

: 6141-27-1
(2S,4S)-4-methylglutamic acid

Guidance literature:: dimethyl (2S,4S)-N-(tert-butoxycarbonyl)-4-methylglutamate; With hydrogenchloride; In water; at 80 ℃; for 6h; Inert atmosphere;

With methyloxirane; at 20 ℃; for 0.5h;
DOI:10.1002/chem.201903725

Reference yield: 73.0%

: dilithium (S)-4-methyl-2-oxoglutarate

: 6141-27-1
(2S,4S)-4-methylglutamic acid

Guidance literature:: With Cysteine sulfinic acid; pyridoxal 5'-phosphate; glutamic oxalacetic transaminase; In water; at 20 ℃; for 24h; pH=7; Enzymatic reaction;
DOI:10.1002/(SICI)1099-0690(199912)1999:12<3403::AID-EJOC3403>3.0.CO;2-U

Reference yield: 44.0%

: 55601-64-4
4-methyl-2-ketoglutaric acid

: 31137-74-3
(2S,4R)-4-methylglutamic acid

: 6141-27-1
(2S,4S)-4-methylglutamic acid

Guidance literature:: 4-methyl-2-ketoglutaric acid; In water; at 20 ℃; for 2h; pH=7.6; Enzymatic reaction;

With pyridoxal 5'-phosphate; Escherichia coli branched chain aminotransferase; Escherichia coli aspartate aminotransferase; In sodium hydroxide; at 20 ℃; for 15h; pH=7.6; Further stages.; Enzymatic reaction;
DOI:10.1021/jo070805q