(1-benzyl-1H-benzimidazol-2-yl)methanol

Base Information

• Chemical Name: (1-benzyl-1H-benzimidazol-2-yl)methanol
• CAS No.: 6646-70-4
• Molecular Formula: C15H14N2O
• Molecular Weight: 238.289
• Hs Code.: 2933990090
• European Community (EC) Number: 840-115-0
• DSSTox Substance ID: DTXSID10354102
• Nikkaji Number: J2.489.658G
• Wikidata: Q82132057
• Mol file: 6646-70-4.mol

Synonyms:(1-benzyl-1H-benzimidazol-2-yl)methanol;6646-70-4;(1-benzylbenzimidazol-2-yl)methanol;(1-BENZYL-1H-BENZO[D]IMIDAZOL-2-YL)METHANOL;(1-benzyl-1H-1,3-benzodiazol-2-yl)methanol;Cambridge id 5525731;Oprea1_135244;Oprea1_319209;IFLab1_001614;SCHEMBL15568834;DTXSID10354102;HMS1416J08;CCG-17125;MFCD00182174;STK213511;AKOS000272145;LS-07303;BB 0219485;CS-0248034;EN300-38868;E83823;AB00087358-01;AF-615/31154005;SR-01000442122;SR-01000442122-1;Z25755080

Chemical Property of (1-benzyl-1H-benzimidazol-2-yl)methanol

Chemical Property:

• Vapor Pressure: 1.74E-09mmHg at 25°C
• Refractive Index: 1.632
• Boiling Point: 466°C at 760 mmHg
• Flash Point: 235.7°C
• PSA: 38.05000
• Density: 1.18g/cm³
• LogP: 2.57690
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 238.110613074
• Heavy Atom Count: 18
• Complexity: 265

Purity/Quality:

98% ^*data from raw suppliers

(1-Benzyl-1H-benzimidazol-2-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CN2C3=CC=CC=C3N=C2CO

Technology Process of (1-benzyl-1H-benzimidazol-2-yl)methanol

There total 12 articles about (1-benzyl-1H-benzimidazol-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-(Hydroxymethyl)benzimidazole (4856-97-7) → (1-benzyl-1H-benzo[d]imidazol-2-yl)methanol (6646-70-4)

Guidance literature:

2-(Hydroxymethyl)benzimidazole; With potassium carbonate; In N,N-dimethyl-formamide; at 25 ℃; for 0.333333h;

benzyl halide; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2021.116352

Reference yield: 77.0%

2-(Hydroxymethyl)benzimidazole (4856-97-7) + benzyl chloride (100-44-7) → (1-benzyl-1H-benzo[d]imidazol-2-yl)methanol (6646-70-4)

Guidance literature:

2-(Hydroxymethyl)benzimidazole; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃;

benzyl chloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 16h;

DOI:10.1016/j.ejmech.2015.12.049

Reference yield: 75.0%

C17H16N2O2 (944061-83-0) → (1-benzyl-1H-benzo[d]imidazol-2-yl)methanol (6646-70-4)

Guidance literature:

With sodium hydroxide; In methanol; at 20 ℃; for 0.5h;

DOI:10.1080/00397910701265556

upstream raw materials:

C₁₇H₁₆N₂O₂

2-(Hydroxymethyl)benzimidazole

(1H-benzo[d]imidazol-2-yl)methyl acetate

N-acetoxy-2-(acetoxymethyl)benzimidazole

Downstream raw materials:

1-benzyl-1H-benzo[d]imidazole-2-carbaldehyde

4-((1-benzyl-1H-benzo[d]imidazol-2-yl)methyl)piperazine-1-carbaldehyde

1-benzyl-2-(chloromethyl)-1H-benzo[d]imidazole

benzyl 4-((1-benzyl-1H-benzo[d]imidazol-2-yl)methyl)piperazine-1-carboxylate