3,9-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline-2,10-diol

Base Information

Chemical Name:3,9-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline-2,10-diol
CAS No.:16562-14-4
Molecular Formula:C₁₉H₂₁NO₄
Molecular Weight:327.38
Hs Code.:2933990090
DSSTox Substance ID:DTXSID00274461,DTXSID70937112
Nikkaji Number:J829.111J
Wikidata:Q7611023
Pharos Ligand ID:1JBB8D6NS29Z
Metabolomics Workbench ID:143235
ChEMBL ID:CHEMBL595489
Mol file:16562-14-4.mol

Synonyms:D,L-Stepholidine;16562-14-4;3,9-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline-2,10-diol;CHEMBL595489;6H-Dibenzo[a,g]quinolizine-2,10-diol, 5,8,13,13a-tetrahydro-3,9-dimethoxy-;13a-alpha-BERBINE-2,10-DIOL, 3,9-DIMETHOXY-;Probes1_000256;Probes2_000298;SCHEMBL460434;CHEBI:91837;DTXSID00274461;DTXSID70937112;BDBM50152837;HSCI1_000061;AKOS030254427;LS-43451;FT-0628017;FT-0674659;J-010216;Q7611023;BRD-A71203467-001-01-5;3,9-Dimethoxy-5,6,13,13a-tetrahydro-8H-dibenzo[a,g]quinolizine-2,10-diol;3,9-Dimethoxy-5,8,13,13A-Tetrahydro-6H-Isoquino[3,2-A]Isoquinoline-2,10-Diol;3,9-Dimethoxy-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinoline-2,10-diol;3,9-dimethoxy-5,8,13,13alpha-tetrahydro-6h-isoquinolino[3,2-a]isoquinoline-2,10-diol

Suppliers and Price of 3,9-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline-2,10-diol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
D,L-Stepholidine
500ug
$ 496.00

TRC
D,L-Stepholidine
5mg
$ 1695.00

TRC
D,L-Stepholidine
2mg
$ 730.00

TRC
D,L-Stepholidine
1mg
$ 400.00

American Custom Chemicals Corporation
DL-STEPHOLIDINE 95.00%
5MG
$ 1800.00

American Custom Chemicals Corporation
DL-STEPHOLIDINE 95.00%
1MG
$ 725.00

American Custom Chemicals Corporation
DL-STEPHOLIDINE 95.00%
0.5MG
$ 575.00

Total 2 raw suppliers

Chemical Property of 3,9-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline-2,10-diol

Chemical Property:

Melting Point:120-1220C
PSA：62.16000
LogP:2.70840
Storage Temp.:-20°C Freezer
Solubility.:Chloroform (Slightly, Sonicated), Methanol (Slightly)
XLogP3:2.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:327.14705815
Heavy Atom Count:24
Complexity:447

Purity/Quality:

97% ^*data from raw suppliers

D,L-Stepholidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C2C3CC4=C(CN3CCC2=C1)C(=C(C=C4)O)OC)O

Technology Process of 3,9-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline-2,10-diol

There total 100 articles about 3,9-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline-2,10-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: (-)-2-benzyloxy-10-hydroxy-3,9-dimethoxy-5,8,13,13a-tetrahydro-6H-dibenzo[a,g]quinolizine

: 16562-14-4,66142-83-4,16562-13-3
(-)-stepholidine

Guidance literature:: With Raney-Ni; In methanol; Reagent/catalyst;

Reference yield: 92.5%

: 2-benzyloxy-10-hydroxy-3,9-dimethoxy-5,8,13,13a-tetrahydro-6H-dibenzo[a,g]quinolizine L-tartaric acid salt

: 16562-14-4,66142-83-4,16562-13-3
(-)-stepholidine

Guidance literature:: With hydrogenchloride; In ethanol; water; Reagent/catalyst; Reflux;

Reference yield: 86.0%

: 1260522-95-9
14-(S)-3,9-dimethoxyl-2,10-diisopropoxy-tetrahydroprotoberberine

: 16562-14-4,66142-83-4,16562-13-3
(-)-stepholidine

Guidance literature:: With boron trichloride; In dichloromethane; at -78 - 20 ℃; optical yield given as %ee; Inert atmosphere;
DOI:10.3987/COM-10-12056