BETA-LACTOSYL AZIDE

Base Information

• Chemical Name: BETA-LACTOSYL AZIDE
• CAS No.: 69266-16-6
• Molecular Formula: C12H21N3O10
• Molecular Weight: 367.309
• Hs Code.: 29329990
• European Community (EC) Number: 636-204-7
• DSSTox Substance ID: DTXSID90472313
• Nikkaji Number: J1.692.039H
• Wikidata: Q76422023
• Mol file: 69266-16-6.mol

Synonyms:BETA-LACTOSYL AZIDE;1-azido-1-deoxy-β-d-lactopyranoside;1-Azido-1-deoxy-b-D-lactopyranoside

Chemical Property of BETA-LACTOSYL AZIDE

Chemical Property:

• Melting Point: 120 °C(lit.)
• PSA: 219.05000
• LogP: -4.62644
• Storage Temp.: ?20°C
• XLogP3: -3.2
• Hydrogen Bond Donor Count: 7
• Hydrogen Bond Acceptor Count: 12
• Rotatable Bond Count: 5
• Exact Mass: 367.12269388
• Heavy Atom Count: 25
• Complexity: 492

Purity/Quality:

99%, ^*data from raw suppliers

1-Azido-1-deoxy-b-D-lactopyranoside ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)N=[N+]=[N-])CO)O)O)O)O
• Isomeric SMILES: C([C@@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)O[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2O)O)N=[N+]=[N-])CO)O)O)O)O

Technology Process of BETA-LACTOSYL AZIDE

There total 6 articles about BETA-LACTOSYL AZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

lactosyl azide (30854-62-7) → β-D-lactosyl azide (69266-16-6)

Guidance literature:

With sodium methylate; In methanol; for 2h; pH=9;

DOI:10.1080/07328309908544050

Reference yield: 99.0%

LACTOSE (5965-66-2) → β-D-lactosyl azide (69266-16-6)

Guidance literature:

With sodium azide; 2-chloro-1,3-dimethylimidazolinium chloride; triethylamine; In water-d2;

DOI:10.1021/acs.bioconjchem.5b00101

Reference yield:

2,3,6,2',3',4',6'-hepta-O-acetyl-lactosyl bromide (4753-07-5) → β-D-lactosyl azide (69266-16-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / NaN₃; aq. NaHCO₃; Bu₄NHSO₄ / CH₂Cl₂ / 2 h / 20 °C

2: 97 percent / NaOMe / methanol / 20 °C

With sodium azide; sodium methylate; tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate; In methanol; dichloromethane;

DOI:10.1021/ja0561690

upstream raw materials:

lactosyl azide

2,3,6,2',3',4',6'-hepta-O-acetyl-lactosyl bromide

1',2',3',6',2,3,4,6-octa-O-acetyl-β-D-lactose

lactose octaacetate

Downstream raw materials:

O-(3,4-O-isopropylidene-2,6-di-O-benzoyl-β-D-galactopyranosyl)-(1->4)-2,3,6-tri-O-benzoyl-β-D-glucopyranosyl azide

O-(2,6-di-O-benzoyl-β-D-galactopyranosyl)-(1->4)-2,3,6-tri-O-benzoyl-β-D-glucopyranosyl azide

1,4-di[1-(β-D-galactopyranosyl-(1->4)-β-D-glucopyranosyl)-1,2,3-triazol-4-ylmethyloxy]benzene

lactosyl azide