3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)guanosine

Base Information

• Chemical Name: 3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)guanosine
• CAS No.: 69304-44-5
• Molecular Formula: C22H39N5O6Si2
• Molecular Weight: 525.753
• Mol file: 69304-44-5.mol

Synonyms:3',5'-O-(1,1,3,3-TETRAISOPROPYLDISILOXAN-1,3-DIYL)-GUANOSINE;3',5'-(TETRAISOPROPYL-DISILOXANE-1,3-DIYL)-GUANOSINE;3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)guanosine

Chemical Property of 3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)guanosine

Chemical Property:

• PSA: 146.74000
• LogP: 3.49770

Purity/Quality:

97% ^*data from raw suppliers

3'',5''-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)guanosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3'',5''-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)guanosine (CAS# 69304-44-5) is a silicon-containing hindered nucleoside, used as antiflaviviridae agents against BVDV, YFV, DENV, and WNV viruses in cell-based assays.

Technology Process of 3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)guanosine

There total 6 articles about 3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)guanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane (69304-37-6) + G (118-00-3) → 3',5'-O-1,1,3,3-tetraisopropyldisiloxan-1,3-diyl-guanosine (69304-44-5)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; for 0.75h; Ambient temperature;

DOI:10.1080/07328319908045600

Reference yield: 83.8%

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane (69304-37-6) + guanosine (118-00-3) → 3',5'-O-TIDPS-guanosine (69304-44-5)

Guidance literature:

With pyridine; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

Reference yield:

1,1,3,3-tetraisopropyldisiloxane (18043-71-5) → 3',5'-O-1,1,3,3-tetraisopropyldisiloxan-1,3-diyl-guanosine (69304-44-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / Cl₂ / CCl₄ / 0.5 h

2: 70 percent / pyridine / dimethylformamide / 5 h

With pyridine; chlorine; In tetrachloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja00350a052

upstream raw materials:

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

G

diisopropylsilanol

1,1,3,3-tetraisopropyldisiloxane

Downstream raw materials:

9-β-D-arabinofuranosylguanine

2'-O-methylthylthiomethylguanosine

9-((2R,3R,3aS,9aR)-3-Hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-1,9-dihydro-purin-6-one

6-O-(tert-Butyldiphenylsilyl)-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine