3-(Methoxymethoxy)-1-butanol

Base Information

• Chemical Name: 3-(Methoxymethoxy)-1-butanol
• CAS No.: 60405-27-8
• Molecular Formula: C6H14O3
• Molecular Weight: 134.17356
• Hs Code.: 2909499000
• DSSTox Substance ID: DTXSID90569732
• Nikkaji Number: J1.270.046F
• Mol file: 60405-27-8.mol

Synonyms:3-(METHOXYMETHOXY)-1-BUTANOL;60405-27-8;3-(METHOXYMETHOXY)BUTAN-1-OL;3-methyl-4,6-dioxa-1-heptanol;DTXSID90569732;AKOS006306268

Chemical Property of 3-(Methoxymethoxy)-1-butanol

Chemical Property:

• PSA: 38.69000
• LogP: 0.37780
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 134.094294304
• Heavy Atom Count: 9
• Complexity: 56.3

Purity/Quality:

98%Min ^*data from raw suppliers

3-(METHOXYMETHOXY)BUTAN-1-OL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CCO)OCOC

Technology Process of 3-(Methoxymethoxy)-1-butanol

There total 5 articles about 3-(Methoxymethoxy)-1-butanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-Acetoxy-3-(methoxymethoxy)butane (167563-42-0) → 3-(Methoxymethoxy)-1-butanol (60405-27-8)

Guidance literature:

With potassium carbonate; In methanol; for 1.5h; Ambient temperature;

DOI:10.1021/jo00113a037

Reference yield: 94.0%

tert-butyl-(3-methoxymethoxy-butoxy)-dimethyl-silane → 3-(Methoxymethoxy)-1-butanol (60405-27-8)

Guidance literature:

With polymer-supported dicyanoketene acetal; water; In acetonitrile; at 20 ℃; for 0.5h;

DOI:10.1055/s-1999-3000

Reference yield:

1-acetoxy-3-(chloromethoxy)butane (93185-29-6) → 3-(Methoxymethoxy)-1-butanol (60405-27-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / diethyl ether / 1 h / 20 °C / Inert atmosphere; Cooling with ice

2: potassium carbonate / methanol; water / 2 h / 20 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; diethyl ether; water;

DOI:10.15227/orgsyn.075.0177

upstream raw materials:

1-Acetoxy-3-(methoxymethoxy)butane

1-acetoxy-3-(chloromethoxy)butane

4-methyl-1,3-dioxane