DL-2-Chloro-5-nitrophenylalanine

Base Information

• Chemical Name: DL-2-Chloro-5-nitrophenylalanine
• CAS No.: 603941-08-8
• Molecular Formula: C9H9ClN2O4
• Molecular Weight: 244.63176
• Mol file: 603941-08-8.mol

Synonyms:DL-2-Chloro-5-nitrophenylalanine

Chemical Property of DL-2-Chloro-5-nitrophenylalanine

Chemical Property:

Purity/Quality:

99%+, ^*data from raw suppliers

DL-2-CHLORO-5-NITROPHENYLALANINE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of DL-2-Chloro-5-nitrophenylalanine

There total 8 articles about DL-2-Chloro-5-nitrophenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

ethyl rac-2-amino-3-(2-chloro-5-nitrophenyl)propionate hydrochloride (1402454-77-6) → (S)-2-amino-3-(2-chloro-5-nitrophenyl)propionic acid (1270144-57-4,603941-08-8) + (R)-2-amino-3-(2-chloro-5-nitrophenyl)propionic acid (1269792-05-3,603941-08-8) + ethyl (R)-2-amino-3-(2-chloro-5-nitrophenyl)propionate (1402454-81-2)

Guidance literature:

With protease; at 30 ℃; for 21h; pH=7; optical yield given as %ee; aq. phosphate buffer;

DOI:10.1002/chem.201200990

Reference yield: 39.0%

ethyl rac-2-amino-3-(2-chloro-5-nitrophenyl)propionate hydrochloride (1402454-77-6) → (S)-2-amino-3-(2-chloro-5-nitrophenyl)propionic acid (1270144-57-4,603941-08-8) + (R)-2-amino-3-(2-chloro-5-nitrophenyl)propionic acid (1269792-05-3,603941-08-8) + ethyl (R)-2-amino-3-(2-chloro-5-nitrophenyl)propionate (1402454-81-2)

Guidance literature:

With protease; at 30 ℃; for 21h; pH=7; optical yield given as %ee; aq. phosphate buffer;

DOI:10.1002/chem.201200990

Reference yield:

ethyl rac-2-amino-3-(2-chloro-5-nitrophenyl)propionate (603945-47-7) → (S)-2-amino-3-(2-chloro-5-nitrophenyl)propionic acid (1270144-57-4,603941-08-8) + (R)-2-amino-3-(2-chloro-5-nitrophenyl)propionic acid (1269792-05-3,603941-08-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / water; acetone

2: protease / 21 h / 30 °C / pH 7 / aq. phosphate buffer

With hydrogenchloride; In water; acetone;

DOI:10.1002/chem.201200990

upstream raw materials:

ethyl rac-2-amino-3-(2-chloro-5-nitrophenyl)propionate hydrochloride

ethyl rac-2-amino-3-(2-chloro-5-nitrophenyl)propionate

1-chloro-2-(chloromethyl)-4-nitrobenzene

1-chloro-2-(chloromethyl)benzene

Downstream raw materials:

(S)-2-amino-3-(2-chloro-5-nitrophenyl)propionic acid hydrochloride

Refernces