Bis(4-methoxyphenyl) sulfone

Base Information

• Chemical Name: Bis(4-methoxyphenyl) sulfone
• CAS No.: 3112-80-9
• Molecular Formula: C14H14 O4 S
• Molecular Weight: 278.329
• NSC Number: 43075
• DSSTox Substance ID: DTXSID80285873
• Nikkaji Number: J1.453.289G
• Wikidata: Q82021404
• ChEMBL ID: CHEMBL376896
• Mol file: 3112-80-9.mol

Synonyms:bis(4-methoxyphenyl) sulfone;3112-80-9;1-methoxy-4-(4-methoxyphenyl)sulfonylbenzene;Benzene, 1,1'-sulfonylbis[4-methoxy-;4,4'-Sulfonylbis(methoxybenzene);NSC43075;ChemDiv3_000542;Oprea1_787554;MLS000570302;SCHEMBL835692;4,4'-Dimethoxy-diphenylsulfon;CHEMBL376896;DTXSID80285873;HMS1474I14;HMS2323A17;NSC-43075;AKOS001027116;CCG-103816;NCGC00173744-01;SMR000150348;F72395;SR-01000398084;SR-01000398084-1;1-METHOXY-4-(4-METHOXYBENZENESULFONYL)BENZENE;BRD-K09796190-001-01-7;Z54338233

Chemical Property of Bis(4-methoxyphenyl) sulfone

Chemical Property:

• Boiling Point: 444.7°Cat760mmHg
• Flash Point: 222.8°C
• Density: 1.232g/cm³
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 278.06128010
• Heavy Atom Count: 19
• Complexity: 327

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)S(=O)(=O)C2=CC=C(C=C2)OC

Technology Process of Bis(4-methoxyphenyl) sulfone

There total 51 articles about Bis(4-methoxyphenyl) sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

bis(4-methoxyphenyl)sulfide (3393-77-9) → bis(p-anisyl)sulfone (3112-80-9)

Guidance literature:

With 2,2,4,4,6,6-hexachloro-1,3,5-triaza-2,4,6-triphosphorine; dihydrogen peroxide; at 25 ℃; for 0.25h; chemoselective reaction; Neat (no solvent);

DOI:10.1021/jo1011784

Reference yield: 93.0%

4-methoxybenzenesulfonyl hydrazide (1950-68-1) + 1-((4-methoxyphenyl)diazenyl)pyrrolidine (36651-93-1) → bis(p-anisyl)sulfone (3112-80-9)

Guidance literature:

With 1-methylimidazole hydrogen sulfate; copper(II) acetate monohydrate; In ethanol; at 20 ℃; for 12h;

DOI:10.1016/j.tet.2018.09.059

Reference yield: 91.0%

sodium 4-methoxybenzenesulfinate (6462-50-6) → bis(p-anisyl)sulfone (3112-80-9)

Guidance literature:

With copper diacetate; In acetonitrile; at 60 ℃; for 3h;

DOI:10.3184/174751914X13946336636551

upstream raw materials:

methyl bromide

4,4'-sulfonediphenol

bis(4-methoxyphenyl) sulfoxide

bis(4-methoxyphenyl)sulfide

Downstream raw materials:

bis-(4-methoxy-3,5-dinitro-phenyl)-sulfone

4-methoxybenzenesulfonic acid

phenylsulfonyl fluoride

2-(4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Refernces

• 1、 Cornella, Josep,Magre, Marc. "Redox-Neutral Organometallic Elementary Steps at Bismuth: Catalytic Synthesis of Aryl Sulfonyl Fluorides". supporting information. p. 21497 - 21502. Retrieved 2022/01/03.
• 2、 Zhu, Haibo,Yang, Liu,Meng, Jia,Xie, Zongbo,Le, Zhang-Gao,Tu, Tao. "Pd/NHC-catalyzed arylsulfonylation of boronic acids: A general and direct protocol to access diarylsulfones". supporting information. . Retrieved 2020/12/29.