Chemical Property of Neurotensin
Chemical Property:
- PSA：668.69000
- Density:1.46g/cm3
- LogP:4.50630
- Solubility.:insoluble in EtOH; ≥15.33 mg/mL in DMSO; ≥22.55 mg/mL in H2O
- Purity/Quality:
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99%, *data from raw suppliers
Neurotensin *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
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Biological functions
NT was first isolated based on hypotensive action
and peripheral vasodilation.1
In the central nervous system,
NT exerts various CNS effects, including hypothermia,
analgesia, modulation of dopamine neurotransmission,
stimulation of anterior pituitary hormone (ACTH, CRH,
DA, GnRH, and SS) release, central control of blood
pressure, inhibition of food intake, and sleep-wake regulation. In the gastrointestinal tract, NT exerts the effects of
pancreatic endocrine secretion and colonic motility, and a
decrease in gastric acid secretion.
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Description
Neurotensin, a hypotensive peptide first isolated from the bovine hypothalamus, neurotensin acts as a neurotransmitter and neurotransmodulator in the central nervous system, and also as a
local hormone in the small intestine. Neurotensin (NT) is a tridecapeptide that was originally isolated from extracts of the bovine hypothalamus
in 1973, based on its ability to cause a visible vasodilation
in the exposed cutaneous regions of anesthetized rats.
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Uses
Neurotensin is a selective, non-competitive NMDA receptor antagonist.
