4,7-Methano-1H-indene-3-methanol,3a,4,7,7a-tetrahydro-1-hydroxy--alpha--methyl-,(-alpha-R,1R,3aS,4R,7S,7aR)-(9CI)

Base Information

Chemical Name:4,7-Methano-1H-indene-3-methanol,3a,4,7,7a-tetrahydro-1-hydroxy--alpha--methyl-,(-alpha-R,1R,3aS,4R,7S,7aR)-(9CI)
CAS No.:672337-30-3
Molecular Formula:C₁₂H₁₆O₂
Molecular Weight:192.258
Hs Code.:
Mol file:672337-30-3.mol

Synonyms:4,7-Methano-1H-indene-3-methanol,3a,4,7,7a-tetrahydro-1-hydroxy--alpha--methyl-,(-alpha-R,1R,3aS,4R,7S,7aR)-(9CI)

Suppliers and Price of 4,7-Methano-1H-indene-3-methanol,3a,4,7,7a-tetrahydro-1-hydroxy--alpha--methyl-,(-alpha-R,1R,3aS,4R,7S,7aR)-(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4,7-Methano-1H-indene-3-methanol,3a,4,7,7a-tetrahydro-1-hydroxy--alpha--methyl-,(-alpha-R,1R,3aS,4R,7S,7aR)-(9CI)

Chemical Property:

Melting Point:145-146 °C(Solv: chloroform (67-66-3))
Boiling Point:350.7±42.0 °C(Predicted)
PKA:14.01±0.40(Predicted)
PSA：40.46000
Density:1.247±0.06 g/cm3(Predicted)
LogP:1.10640

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4,7-Methano-1H-indene-3-methanol,3a,4,7,7a-tetrahydro-1-hydroxy--alpha--methyl-,(-alpha-R,1R,3aS,4R,7S,7aR)-(9CI)

There total 4 articles about 4,7-Methano-1H-indene-3-methanol,3a,4,7,7a-tetrahydro-1-hydroxy--alpha--methyl-,(-alpha-R,1R,3aS,4R,7S,7aR)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 672337-29-0
(3aS,4R,7S,7aR)-3-Acetyl-3a,4,7,7a-tetrahydro-4,7-methano-inden-1-one

: 672337-04-1
(1R,3aS,4R,7S,7aR)-3-((S)-1-Hydroxy-ethyl)-3a,4,7,7a-tetrahydro-1H-4,7-methano-inden-1-ol

: 672337-30-3,672337-17-6,672337-31-4,672337-04-1
(1R,3aS,4R,7S,7aR)-3-((R)-1-Hydroxy-ethyl)-3a,4,7,7a-tetrahydro-1H-4,7-methano-inden-1-ol

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; toluene; at -78 ℃; for 0.25h;
DOI:10.1021/jo035430x

Reference yield:

: 111136-75-5
(-)-(1R,2R,6R,7S)-tricyclo[5.2.1.0^2,6]deca-4,8-dien-3-one

: 672337-30-3,672337-17-6,672337-31-4,672337-04-1
(1R,3aS,4R,7S,7aR)-3-((R)-1-Hydroxy-ethyl)-3a,4,7,7a-tetrahydro-1H-4,7-methano-inden-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / CuI / tetrahydrofuran / 0.5 h / -35 °C

2: 84 percent / CuCl; O₂ / PdCl₂ / dimethylformamide; H₂O / 10 h / 50 °C

3: 73 percent / p-TsOH; DDQ / dioxane / 20 h / Heating

4: 66 percent / DIBALH / tetrahydrofuran; toluene / 0.25 h / -78 °C

With copper(l) iodide; oxygen; diisobutylaluminium hydride; toluene-4-sulfonic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; copper(l) chloride; palladium dichloride; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo035430x

Reference yield:

: 672337-27-8
(3R,3aS,4R,7S,7aR)-3-Vinyl-2,3,3a,4,7,7a-hexahydro-4,7-methano-inden-1-one

: 672337-30-3,672337-17-6,672337-31-4,672337-04-1
(1R,3aS,4R,7S,7aR)-3-((R)-1-Hydroxy-ethyl)-3a,4,7,7a-tetrahydro-1H-4,7-methano-inden-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / CuCl; O₂ / PdCl₂ / dimethylformamide; H₂O / 10 h / 50 °C

2: 73 percent / p-TsOH; DDQ / dioxane / 20 h / Heating

3: 66 percent / DIBALH / tetrahydrofuran; toluene / 0.25 h / -78 °C

With oxygen; diisobutylaluminium hydride; toluene-4-sulfonic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; copper(l) chloride; palladium dichloride; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo035430x