N-T-BOC-4,4-DIFLUOROCYCLOHEXYLAMINE

Base Information

• Chemical Name: N-T-BOC-4,4-DIFLUOROCYCLOHEXYLAMINE
• CAS No.: 675112-67-1
• Molecular Formula: C11H19F2NO2
• Molecular Weight: 235.274
• Hs Code.: 2924299090
• Mol file: 675112-67-1.mol

Synonyms:N-T-BOC-4,4-DIFLUOROCYCLOHEXYLAMINE

Chemical Property of N-T-BOC-4,4-DIFLUOROCYCLOHEXYLAMINE

Chemical Property:

• Melting Point: 119-122 °C
• Boiling Point: 293.2±40.0 °C(Predicted)
• PKA: 11.46±0.40(Predicted)
• PSA: 38.33000
• Density: 1.09±0.1 g/cm3(Predicted)
• LogP: 3.47990
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl 4,4-difluorocyclohexylcarbamate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-T-BOC-4,4-DIFLUOROCYCLOHEXYLAMINE

There total 12 articles about N-T-BOC-4,4-DIFLUOROCYCLOHEXYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-(tert-butoxycarbonyl)-4-aminocyclohexanone (179321-49-4) → tert-butyl (4,4-difluorocyclohexyl)carbamate (675112-67-1)

Guidance literature:

With diethylamino-sulfur trifluoride; In dichloromethane; for 15h;

Reference yield: 70.0%

N-(tert-butoxycarbonyl)-4-aminocyclohexanone (179321-49-4) → tert-butyl (4,4-difluorocyclohexyl)carbamate (675112-67-1) + tert-butyl (4-fluorocyclohex-3-en-1-yl)carbamate (675112-69-3)

Guidance literature:

With diethylamino-sulfur trifluoride; In dichloromethane; at -5 - 20 ℃; Inert atmosphere;

Reference yield: 70.0%

N-(tert-butoxycarbonyl)-4-aminocyclohexanone (179321-49-4) → tert-butyl (4,4-difluorocyclohexyl)carbamate (675112-67-1) + tert-butyl (4-fluorocyclohex-3-enyl)carboxylate

Guidance literature:

With diethylamino-sulfur trifluoride; In dichloromethane; at 20 ℃; Cooling with ice;

upstream raw materials:

N-(tert-butoxycarbonyl)-4-aminocyclohexanone

4,4-difluorocyclohexylamine hydrochloride

di-tert-butyl dicarbonate

p-hydroxycyclohexylamine

Downstream raw materials:

4,4-difluorocyclohexylamine hydrochloride

4-fluoro-3-cyclohexen-1-amine

4,4-difluorocyclohexan-1-amine

4, 4-difluorocyclohexanamine tosic salt