1-NAPHTHALENAMINE, 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-, HYDROCHLORIDE, (1S,4S)-

Base Information

Chemical Name:1-NAPHTHALENAMINE, 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-, HYDROCHLORIDE, (1S,4S)-
CAS No.:675126-10-0
Molecular Formula:C16H16Cl3N
Molecular Weight:328.66
Hs Code.:
Mol file:675126-10-0.mol

Synonyms:NORSERTRALINE HCL;DESMETHYL SERTRALINE HCL;1-NAPHTHALENAMINE, 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-, HYDROCHLORIDE, (1S,4S)-;(1S,4S)- 4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine Hydrochloride;(1S,4S)-N-Desmethyl Sertraline Hydrochloride;(1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride (1:1);1,2,3,4-tetrahydro-,hydrochloride, (1S,4S)-;1-Naphthalenamine, 4-(3,4-dichlorophenyl)-

Suppliers and Price of 1-NAPHTHALENAMINE, 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-, HYDROCHLORIDE, (1S,4S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(1S,4S)-N-DesmethylSertralineHydrochloride
1mg
$ 145.00

Medical Isotopes, Inc.
(1S,4S)-N-DesmethylSertralineHCl
1 mg
$ 850.00

Biosynth Carbosynth
(1S,4S)-N-Desmethyl sertraline hydrochloride
2 mg
$ 500.00

Biosynth Carbosynth
(1S,4S)-N-Desmethyl sertraline hydrochloride
10 mg
$ 1500.00

Biosynth Carbosynth
(1S,4S)-N-Desmethyl sertraline hydrochloride
25 mg
$ 3250.00

American Custom Chemicals Corporation
(1S,4S)-N-DESMETHYL SERTRALINE HYDROCHLORIDE 95.00%
10MG
$ 1501.50

American Custom Chemicals Corporation
(1S,4S)-N-DESMETHYL SERTRALINE HYDROCHLORIDE 95.00%
1MG
$ 693.00

Total 15 raw suppliers

Chemical Property of 1-NAPHTHALENAMINE, 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-, HYDROCHLORIDE, (1S,4S)-

Chemical Property:

Melting Point:301-303°C
PSA：26.02000
LogP:6.42120
Storage Temp.:Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98%Min ^*data from raw suppliers

(1S,4S)-N-DesmethylSertralineHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses A metabolite of Sertraline. N-Desmethyl sertraline is significantly less active analogue as compared to the methylated compound, Sertraline

Technology Process of 1-NAPHTHALENAMINE, 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-, HYDROCHLORIDE, (1S,4S)-

There total 15 articles about 1-NAPHTHALENAMINE, 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-, HYDROCHLORIDE, (1S,4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1097616-52-8
N-((1S,4R)-1-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-4-yl)acetamide

: 675126-08-6,1310676-34-6,675126-10-0,91797-57-8
(1R,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride salt

Guidance literature:: With hydrogenchloride; water; In isopropyl alcohol; at 110 ℃; for 120h; optical yield given as %ee;
DOI:10.1002/chem.200802303

Reference yield: 71.0%

: (1R,4S)-4-(3,4-dichlorophenyl)-N-[(1R)-1-(4-methoxyphenyl)ethyl]-1,2,3,4-tetrahydronaphthalen-1-amine

: 675126-08-6,1310676-34-6,675126-10-0,91797-57-8
(1R,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride salt

Guidance literature:: (1R,4S)-4-(3,4-dichlorophenyl)-N-[(1R)-1-(4-methoxyphenyl)ethyl]-1,2,3,4-tetrahydronaphthalen-1-amine; With trifluoroacetic acid; for 24h; Reflux;

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 17h;