S,S,S-CSDPHEN

Base Information

• Chemical Name: S,S,S-CSDPHEN
• CAS No.: 676270-65-8
• Molecular Formula: C24H30N2O3S
• Molecular Weight: 426.58
• Mol file: 676270-65-8.mol

Synonyms:S,S,S-CSDPHEN

Chemical Property of S,S,S-CSDPHEN

Chemical Property:

• Vapor Pressure: 4.06E-13mmHg at 25°C
• Refractive Index: 1.629
• Boiling Point: 572.6°C at 760 mmHg
• PKA: 9.50±0.10(Predicted)
• Flash Point: 300.1°C
• PSA: 97.64000
• Density: 1.28g/cm³
• LogP: 5.66690

Purity/Quality:

S,S,S-CSDPHEN 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of S,S,S-CSDPHEN

There total 2 articles about S,S,S-CSDPHEN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(S,S)-1,2-diphenyl-1,2-diaminoethane (29841-69-8) + Camphorsulfonyl chloride (21286-54-4) → (S,S,S)-CsDPEN (676270-65-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1039/d1ob01844b

Reference yield:

(1S)-10-camphorsulfonic acid (3144-16-9,61380-66-3) → (S,S,S)-CsDPEN (676270-65-8)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 12 h / Reflux

2: triethylamine / dichloromethane / 5 h / 0 - 20 °C

With thionyl chloride; triethylamine; In dichloromethane;

DOI:10.1016/j.tetasy.2011.04.017

upstream raw materials:

(S,S)-1,2-diphenyl-1,2-diaminoethane

Camphorsulfonyl chloride

(1S)-10-camphorsulfonic acid

Refernces

• 1、 Lu, Chuanjun,Luo, Zonghua,Huang, Ling,Li, Xingshu. "The Ru-catalyzed enantioselective preparation of chiral halohydrins and their application in the synthesis of (R)-clorprenaline and (S)-sotalol". experimental part. p. 722 - 727. Retrieved 2011/08/06.