(1S,2S)-1,2-Di(naphthalen-1-yl)ethane-1,2-diamine dihydrochloride

Base Information

Chemical Name:(1S,2S)-1,2-Di(naphthalen-1-yl)ethane-1,2-diamine dihydrochloride
CAS No.:677723-26-1
Molecular Formula:C22H20N2
Molecular Weight:312.414
Hs Code.:
DSSTox Substance ID:DTXSID30697765
Mol file:677723-26-1.mol

Synonyms:(1S,2S)-1,2-Di(naphthalen-1-yl)ethane-1,2-diamine dihydrochloride;(1R,2R)-1,2-Di-1-naphthalenyl-1,2-ethanediamineHydrochloride;(S, S)-1,2-Bis(1-naphthyl)-1,2-ethanediamine dihydrochloride;677723-26-1;SCHEMBL19951713;DTXSID30697765;SB83724;1,2-Di(naphthalen-1-yl)ethane-1,2-diamine dihydrochloride;1,2-Di(naphthalen-1-yl)ethane-1,2-diamine--hydrogen chloride (1/2)

Suppliers and Price of (1S,2S)-1,2-Di(naphthalen-1-yl)ethane-1,2-diamine dihydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
(1S, 2S)-1,2-di-1-Naphthyl-ethylenediamine dihydrochloride 97%
1 g
$ 406.00

Sigma-Aldrich
(1S, 2S)-1,2-di-1-Naphthyl-ethylenediamine dihydrochloride 97%
100 mg
$ 77.00

Total 3 raw suppliers

Chemical Property of (1S,2S)-1,2-Di(naphthalen-1-yl)ethane-1,2-diamine dihydrochloride

Chemical Property:

Melting Point:219-224 °C
Boiling Point:529.8±45.0 °C(Predicted)
PKA:8.04±0.30(Predicted)
PSA：52.04000
Density:1.201±0.06 g/cm3(Predicted)
LogP:7.69740
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:384.1160041
Heavy Atom Count:26
Complexity:371

Purity/Quality:

98%Min ^*data from raw suppliers

(1S, 2S)-1,2-di-1-Naphthyl-ethylenediamine dihydrochloride 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xn
Statements: 22-36/37/38
Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C=CC=C2C(C(C3=CC=CC4=CC=CC=C43)N)N.Cl.Cl

Technology Process of (1S,2S)-1,2-Di(naphthalen-1-yl)ethane-1,2-diamine dihydrochloride

There total 9 articles about (1S,2S)-1,2-Di(naphthalen-1-yl)ethane-1,2-diamine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: (1R,2R)-1,2-di(naphthalen-1-yl)ethane-1,2-diamine

: 677723-26-1
(1S,2S)-1,2-di(naphthalen-1-yl)ethane-1,2-diamine

Guidance literature:: With (5R,5'R)-4,4,4',4'-tetrakis(2,5-dimethylphenyl)-5,5'-diphenyl-2,2'-bi(1,3,2-dioxaborolane); In tetrahydrofuran; methanol; at 20 - 30 ℃; Schlenk technique; Inert atmosphere; Sealed tube;

With hydrogenchloride; In methanol; water; pH=Ca. 3;

Reference yield:

: 95048-05-8
1-naphthaldimine

: (1R,2R)-1,2-di(naphthalen-1-yl)ethane-1,2-diamine

: 677723-26-1
(1S,2S)-1,2-di(naphthalen-1-yl)ethane-1,2-diamine

Guidance literature:: 1-naphthaldimine; With (5R,5'R)-4,4,4',4'-tetrakis(2,5-dimethylphenyl)-5,5'-diphenyl-2,2'-bi(1,3,2-dioxaborolane); In tetrahydrofuran; methanol; at 20 ℃; for 24h;

With hydrogenchloride; In methanol; enantioselective reaction;
DOI:10.1021/jacs.0c04558

Reference yield:

: 66-77-3
1-naphthaldehyde

: (1R,2R)-1,2-di(naphthalen-1-yl)ethane-1,2-diamine

: 677723-26-1
(1S,2S)-1,2-di(naphthalen-1-yl)ethane-1,2-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: ammonia / methanol; tetrahydrofuran / 1 h / 20 °C

2: (5R,5'R)-4,4,4',4'-tetrakis(2,5-dimethylphenyl)-5,5'-diphenyl-2,2'-bi(1,3,2-dioxaborolane) / methanol; tetrahydrofuran / 24 h / 20 °C

With ammonia; (5R,5'R)-4,4,4',4'-tetrakis(2,5-dimethylphenyl)-5,5'-diphenyl-2,2'-bi(1,3,2-dioxaborolane); In tetrahydrofuran; methanol;
DOI:10.1021/jacs.0c04558