16A-BROMOANDROSTERONE

Base Information

• Chemical Name: 16A-BROMOANDROSTERONE
• CAS No.: 60802-13-3
• Molecular Formula: C21H31BrO3
• Molecular Weight: 411.37
• Mol file: 60802-13-3.mol

Synonyms:

Chemical Property of 16A-BROMOANDROSTERONE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.561
• Boiling Point: 448.561°C at 760 mmHg
• Flash Point: 225.082°C
• Density: 1.31g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 16A-BROMOANDROSTERONE

There total 10 articles about 16A-BROMOANDROSTERONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3α,5α)-androst-16-ene-3,17-diol diacetate (59492-03-4) → (16α)-bromoandrosterone acetate (60802-13-3)

Guidance literature:

With tetrachloromethane; bromine;

Reference yield:

androsterone acetate (1164-95-0) → (16α)-bromoandrosterone acetate (60802-13-3)

Guidance literature:

Multi-step reaction with 2 steps

1: p-TsOH / 14 h / 130 - 140 °C

2: Br₂ / CCl₄ / 0.33 h / -5 °C

With bromine; toluene-4-sulfonic acid; In tetrachloromethane; 1: Acetylation / 2: Bromination;

DOI:10.1021/jm000977e

Reference yield:

cis-androsterone (53-41-8) → (16α)-bromoandrosterone acetate (60802-13-3)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 3 h

2: p-TsOH / 14 h / 130 - 140 °C

3: Br₂ / CCl₄ / 0.33 h / -5 °C

With pyridine; bromine; toluene-4-sulfonic acid; In tetrachloromethane; 1: Acetylation / 2: Acetylation / 3: Bromination;

DOI:10.1021/jm000977e

upstream raw materials:

(3α,5α)-androst-16-ene-3,17-diol diacetate

acetic anhydride

cis-androsterone

androsterone acetate

Downstream raw materials:

3β-Acetoxy-5α-androstano-16,17-dione Bisphenylhydrazone

3β-Acetoxy-5α-androstan-17-one-16β-phenylhyrazine-17-phenylhydrazone

Refernces