4-Amino-3-nitrobenzenesulfonamide

Base Information

• Chemical Name: 4-Amino-3-nitrobenzenesulfonamide
• CAS No.: 2360-19-2
• Molecular Formula: C6H7N3O4S
• Molecular Weight: 217.205
• Hs Code.: 2935009090
• European Community (EC) Number: 853-247-9
• DSSTox Substance ID: DTXSID50379011
• Wikidata: Q72439949
• Mol file: 2360-19-2.mol

Synonyms:4-amino-3-nitrobenzenesulfonamide;2360-19-2;4-Amino-3-nitro-benzenesulfonamide;MFCD00116612;4-amino-3-nitrobenzene-1-sulfonamide;Benzenesulfonamide,4-amino-3-nitro-;Benzenesulfonamide, 4-amino-3-nitro-;SCHEMBL1911571;DTXSID50379011;DZJCUJCWFQPICK-UHFFFAOYSA-N;4-Amino-3-nitrobenzenesulphonamide;AKOS000115242;s10432;NCGC00339131-01;SY019562;CS-0046275;FT-0739829;EN300-01192;AB01331185-02;A878193;12W-0973;Z87002432

Chemical Property of 4-Amino-3-nitrobenzenesulfonamide

Chemical Property:

• Vapor Pressure: 2.15E-09mmHg at 25°C
• Refractive Index: 1.658
• Boiling Point: 480.6 °C at 760 mmHg
• Flash Point: 244.4 °C
• PSA: 140.38000
• Density: 1.639 g/cm³
• LogP: 2.70990
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 1
• Exact Mass: 217.01572689
• Heavy Atom Count: 14
• Complexity: 317

Purity/Quality:

99% ^*data from raw suppliers

4-Amino-3-nitrobenzenesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1S(=O)(=O)N)[N+](=O)[O-])N

Technology Process of 4-Amino-3-nitrobenzenesulfonamide

There total 16 articles about 4-Amino-3-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.47%

4-fluoro-3-nitrobenzene-1-sulfonyl chloride (6668-56-0) → 4-amino-3-nitrobenzenesulfonamide (2360-19-2)

Guidance literature:

With ammonium hydroxide; In acetonitrile; at 10 - 30 ℃; for 8h; Large scale;

Reference yield: 83.0%

(2-Nitro-4-sulfamoyl-phenyl)-carbamic acid ethyl ester (84202-49-3) → 4-amino-3-nitrobenzenesulfonamide (2360-19-2)

Guidance literature:

With sulfuric acid; for 1h; Heating;

Reference yield:

3-nitro-4-(4-nitro-phenoxy)-benzenesulfonyl chloride + ammonium hydroxide → 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + 4-amino-3-nitrobenzenesulfonamide (2360-19-2)

Guidance literature:

upstream raw materials:

4-acetylamino-3-nitro-benzenesulfonic acid amide

(2-Nitro-4-sulfamoyl-phenyl)-carbamic acid ethyl ester

4-(sulfonylphenyl)carbamic acid ethyl ester

sulfanilamide

Downstream raw materials:

2-phenyl-1H-benzo[d]imidazole-5-sulfonamide

4-amino-3-bromo-5-nitrobenzenesulfonamide

2-Nitro-benzene-1,4-disulfonic acid 4-(acetyl-amide) 1-dibutylamide

2-Nitro-benzene-1,4-disulfonic acid 4-amide 1-dibutylamide

Refernces

• 1、 ?al??kan, Burcu,Banoglu, Erden,Gür Maz, Tu??e,Nocentini, Alessio,Supuran, Claudiu T.,Uslu, Azize Gizem. "Benzimidazole derivatives as potent and isoform selective tumor-associated carbonic anhydrase IX/XII inhibitors". supporting information. . Retrieved 2020/01/08.
• 2、 -. "2,3-quinoxalinediones for use as neuroleptics". . . Retrieved 2008/06/13.