Bicyclo[3.1.0]hexane-1-acetic acid, -alpha--methylene- (9CI)

Base Information

• Chemical Name: Bicyclo[3.1.0]hexane-1-acetic acid, -alpha--methylene- (9CI)
• CAS No.: 680179-44-6
• Molecular Formula: C9H12O2
• Molecular Weight: 152.193
• Mol file: 680179-44-6.mol

Synonyms:Bicyclo[3.1.0]hexane-1-acetic acid, -alpha--methylene- (9CI)

Chemical Property of Bicyclo[3.1.0]hexane-1-acetic acid, -alpha--methylene- (9CI)

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Bicyclo[3.1.0]hexane-1-acetic acid, -alpha--methylene- (9CI)

There total 5 articles about Bicyclo[3.1.0]hexane-1-acetic acid, -alpha--methylene- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-(bicyclo[3.1.0]hex-1-yl)-2-oxoacetic Acid Methyl Ester (540764-54-3) → 2-(bicyclo[3.1.0]hex-1-yl)propenoic acid (680179-44-6)

Guidance literature:

With lithium hydroxide; 2,6-di-tert-butyl-4-methyl-phenol; In water; acetone; at 20 ℃; for 24h;

Reference yield: 86.0%

methyl 2-(bicyclo[3.1.0]hex-1-yl)propenoate (540764-52-1) → 2-(bicyclo[3.1.0]hex-1-yl)propenoic acid (680179-44-6)

Guidance literature:

With lithium hydroxide; 2,6-di-tert-butyl-4-methyl-phenol; In water; acetone; at 25 ℃; for 24h;

DOI:10.1002/adsc.200606155

Reference yield:

8-(methoxycarbonyloxy)oct-1-en-6-yne (948896-29-5) → 2-(bicyclo[3.1.0]hex-1-yl)propenoic acid (680179-44-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / PO(OMe)3; P(2-furyl)3; P(OMe)3 / Pd(OAc)2 / methanol / 16 h / 25 °C / 750.06 Torr

2: 86 percent / LiOH; 3,5-di-tert-butyl-4-hydroxytoluene / acetone; H₂O / 24 h / 25 °C

With trimethyl phosphite; lithium hydroxide; trifuran-2-yl-phosphane; 2,6-di-tert-butyl-4-methyl-phenol; phosphorous acid trimethyl ester; palladium diacetate; In methanol; water; acetone;

DOI:10.1002/adsc.200606155

upstream raw materials:

methyl 2-(bicyclo[3.1.0]hex-1-yl)propenoate

8-(methoxycarbonyloxy)oct-1-en-6-yne

octa-7-en-2-yn-1-ol

bromopentene

Refernces

• 1、 -. "Polymerizable bicyclic cyclopropane derivatives and their use for the preparation of dental materials". Page 8-9. . Retrieved 2008/06/13.