Technology Process of Cyclobutanecarboxylic acid, 3,3-difluoro-, ethyl ester (9CI)
There total 2 articles about Cyclobutanecarboxylic acid, 3,3-difluoro-, ethyl ester (9CI) which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: diethylamino-sulfur trifluoride / dichloromethane / 24 h / -10 - 20 °C
2.1: sodium hydroxide; water / pentane; methanol / 75 h / 20 - 60 °C
2.2: pH 1
3.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
With
diethylamino-sulfur trifluoride; water; caesium carbonate; sodium hydroxide;
In
methanol; dichloromethane; N,N-dimethyl-formamide; pentane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium periodate / ruthenium(III) trichloride hydrate / dichloromethane; acetonitrile; water / 5 - 20 °C
2.1: diethylamino-sulfur trifluoride / dichloromethane / 24 h / -10 - 20 °C
3.1: sodium hydroxide; water / pentane; methanol / 75 h / 20 - 60 °C
3.2: pH 1
4.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
With
sodium periodate; diethylamino-sulfur trifluoride; water; caesium carbonate; sodium hydroxide;
ruthenium(III) trichloride hydrate;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; pentane;
