Benzeneethanol, 2-ethyl-5-methoxy- (9CI)

Base Information Edit

Chemical Name:Benzeneethanol, 2-ethyl-5-methoxy- (9CI)
CAS No.:681171-45-9
Molecular Formula:C11H16O2
Molecular Weight:180.247
Hs Code.:
Mol file:681171-45-9.mol

Synonyms:Benzeneethanol, 2-ethyl-5-methoxy- (9CI)

Suppliers and Price of Benzeneethanol, 2-ethyl-5-methoxy- (9CI)

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Chemical Property of Benzeneethanol, 2-ethyl-5-methoxy- (9CI) Edit

Chemical Property:

Boiling Point:285.9±25.0 °C(Predicted)
PKA:14.90±0.10(Predicted)
PSA：29.46000
Density:1.020±0.06 g/cm3(Predicted)
LogP:1.79240

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Benzeneethanol, 2-ethyl-5-methoxy- (9CI)

There total 11 articles about Benzeneethanol, 2-ethyl-5-methoxy- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5020-41-7
2-(3-methoxyphenyl)-ethanol

: 681171-45-9
3-methoxy-6-ethyl-phenethyl alcohol

Guidance literature:: Multi-step reaction with 2 steps

1: AlCl₃ / CH₂Cl₂

2: LiAlH₄; AlCl₃

With lithium aluminium tetrahydride; aluminium trichloride; In dichloromethane; 1: Friedel-Crafts reaction;
DOI:10.1016/j.bmcl.2004.06.043

Reference yield:

: 100-09-4
4-methoxybenzoic acid

: 681171-45-9
3-methoxy-6-ethyl-phenethyl alcohol

Guidance literature:: Multi-step reaction with 9 steps

1.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

1.2: -78 °C / Inert atmosphere

2.1: thionyl chloride / methanol / 3 h / Inert atmosphere; Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 10 °C / Inert atmosphere

4.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 8 h / Inert atmosphere; Reflux

5.1: methyl grignard / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

6.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetonitrile / 8 h / 20 °C / Inert atmosphere

7.1: palladium on activated charcoal; hydrogen / methanol; acetic acid / 10 h / 20 °C / Inert atmosphere

8.1: sodium periodate / water; acetone / 1 h / Inert atmosphere

9.1: sodium tetrahydroborate / methanol; water / 1 h / Inert atmosphere

With sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; thionyl chloride; N,N,N,N,-tetramethylethylenediamine; palladium on activated charcoal; hydrogen; sec.-butyllithium; 4-methylmorpholine N-oxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; methanol; water; acetic acid; ethyl acetate; acetone; acetonitrile;
DOI:10.1002/anie.201210333

Reference yield:

: 79928-69-1
2-formyl-5-methoxyallylbenzene

: 681171-45-9
3-methoxy-6-ethyl-phenethyl alcohol

Guidance literature:: Multi-step reaction with 5 steps

1: methyl grignard / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

2: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetonitrile / 8 h / 20 °C / Inert atmosphere

3: palladium on activated charcoal; hydrogen / methanol; acetic acid / 10 h / 20 °C / Inert atmosphere

4: sodium periodate / water; acetone / 1 h / Inert atmosphere

5: sodium tetrahydroborate / methanol; water / 1 h / Inert atmosphere

With sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; palladium on activated charcoal; hydrogen; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; water; acetic acid; acetone; acetonitrile;
DOI:10.1002/anie.201210333