Benzothiazole, 7-bromo- (7CI,8CI)

Base Information

• Chemical Name: Benzothiazole, 7-bromo- (7CI,8CI)
• CAS No.: 767-70-4
• Molecular Formula: C7H4BrNS
• Molecular Weight: 214.08236
• Hs Code.: 29342000
• Mol file: 767-70-4.mol

Synonyms:7-Bromobenzothiazole;7-bromo-1,3-benzothiazole;benzothiazole, 7-bromo-;7-Bromobenzothiazole;

Chemical Property of Benzothiazole, 7-bromo- (7CI,8CI)

Chemical Property:

• Vapor Pressure: 0.003mmHg at 25°C
• Melting Point: 82 °C
• Refractive Index: 1.718
• Boiling Point: 291.493 °C at 760 mmHg
• PKA: 1.42±0.30(Predicted)
• Flash Point: 130.09 °C
• PSA: 41.13000
• Density: 1.748 g/cm³
• LogP: 3.05880
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

7-Bromobenzothiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzothiazole, 7-bromo- (7CI,8CI)

There total 4 articles about Benzothiazole, 7-bromo- (7CI,8CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

→ 7-bromo-1,3-benzothiazole (767-70-4)

Guidance literature:

With water; caesium carbonate; for 0.166667h; Microwave irradiation;

Reference yield: 75.0%

6-amino-7-bromo-1,3-benzothiazole (769-20-0) → 7-bromo-1,3-benzothiazole (767-70-4)

Guidance literature:

6-amino-7-bromo-1,3-benzothiazole; With sulfuric acid; sodium nitrite; at 20 ℃; for 0.333333h;

With hypophosphorous acid; at 50 ℃;

With sodium carbonate; pH=9 - 10;

Reference yield:

1,3-benzothiazol-6-amine (533-30-2) → 7-bromo-1,3-benzothiazole (767-70-4)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine; acetic acid

2: sodium nitrite; sulfuric acid; hypophosphorous acid

With sulfuric acid; bromine; hypophosphorous acid; acetic acid; sodium nitrite; 2: |Sandmeyer Reaction;

DOI:10.1016/j.bmcl.2012.07.068

upstream raw materials:

7-amino-1,3-benzothiazole

6-amino-7-bromo-1,3-benzothiazole

1,3-benzothiazol-6-amine

Downstream raw materials:

7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]thiazole

2-Bromo-7-(4-fluoro-phenyl)-benzothiazole

7-(4-Fluoro-phenyl)-2-thiophen-3-yl-benzothiazole

4-[7-(4-Fluoro-phenyl)-benzothiazol-2-yl]-thiophene-2-sulfonic acid

Refernces

• 1、 -. "STK4 INHIBITORS FOR TREATMENT OF HEMATOLOGIC MALIGNANCIES". Paragraph 00694. . Retrieved 2017/01/09.
• 2、 -. "New Compounds Useful for Treating CNS Disorders". Page/Page column 1. . Retrieved 2011/05/05.