3aH-Cyclopent[d]isoxazole-3a-methanol,hexahydro-2-methyl-3-propyl-,(3R,3aR,6aR)-(9CI)

Base Information

• Chemical Name: 3aH-Cyclopent[d]isoxazole-3a-methanol,hexahydro-2-methyl-3-propyl-,(3R,3aR,6aR)-(9CI)
• CAS No.: 607405-12-9
• Molecular Formula: C11H21NO2
• Molecular Weight: 199.29
• Mol file: 607405-12-9.mol

Synonyms:3aH-Cyclopent[d]isoxazole-3a-methanol,hexahydro-2-methyl-3-propyl-,(3R,3aR,6aR)-(9CI)

Chemical Property of 3aH-Cyclopent[d]isoxazole-3a-methanol,hexahydro-2-methyl-3-propyl-,(3R,3aR,6aR)-(9CI)

Chemical Property:

• Boiling Point: 120 °C(Press: 0.7 Torr)
• PKA: 14.72±0.10(Predicted)
• PSA: 32.70000
• Density: 1.035±0.06 g/cm3(Predicted)
• LogP: 1.50120

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3aH-Cyclopent[d]isoxazole-3a-methanol,hexahydro-2-methyl-3-propyl-,(3R,3aR,6aR)-(9CI)

There total 2 articles about 3aH-Cyclopent[d]isoxazole-3a-methanol,hexahydro-2-methyl-3-propyl-,(3R,3aR,6aR)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-cyclopentene-1-carboxaldehyde (6140-65-4) + (Z)-N-(n-butylidene)methylamine N-oxide (44603-43-2,127872-09-7) → [(3S,3aS,6aS)-2-methyl-3-propylhexahydro-3aH-cyclopenta[d]isoxazol-3a-yl]methanol (607405-12-9) + [(3R,3aR,6aR)-2-methyl-3-propylhexahydro-3aH-cyclopenta[d]isoxazol-3a-yl]methanol (607405-12-9)

Guidance literature:

1-cyclopentene-1-carboxaldehyde; (Z)-N-(n-butylidene)methylamine N-oxide; With chiral pyrrolidine derivative dihydrochloride; In water; N,N-dimethyl-formamide; at -25 ℃; for 144h;

With sodium tetrahydroborate; In methanol; at 20 ℃; for 0.5h; Further stages. Title compound not separated from byproducts.;

DOI:10.1002/ejoc.200300172

Reference yield:

1-cyclopentene-1-carboxaldehyde (6140-65-4) + (Z)-N-(n-butylidene)methylamine N-oxide (44603-43-2,127872-09-7) → [(3S,3aS,6aS)-2-methyl-3-propylhexahydro-3aH-cyclopenta[d]isoxazol-3a-yl]methanol (607405-12-9) + [(3R,3aR,6aR)-2-methyl-3-propylhexahydro-3aH-cyclopenta[d]isoxazol-3a-yl]methanol (607405-12-9)

Guidance literature:

1-cyclopentene-1-carboxaldehyde; (Z)-N-(n-butylidene)methylamine N-oxide; With chiral pyrrolidine derivative dihydrochloride; In water; N,N-dimethyl-formamide; at -25 ℃; for 144h;

With sodium tetrahydroborate; In methanol; at 20 ℃; for 0.5h; Further stages. Title compound not separated from byproducts.;

DOI:10.1002/ejoc.200300172

upstream raw materials:

1-cyclopentene-1-carboxaldehyde

(Z)-N-(n-butylidene)methylamine N-oxide