Piperazine, 3-ethyl-1-[(4-fluorophenyl)methyl]-, (3R)- (9CI)

Base Information

• Chemical Name: Piperazine, 3-ethyl-1-[(4-fluorophenyl)methyl]-, (3R)- (9CI)
• CAS No.: 685535-16-4
• Molecular Formula: C13H19FN2
• Molecular Weight: 222.306
• Mol file: 685535-16-4.mol

Synonyms:Piperazine, 3-ethyl-1-[(4-fluorophenyl)methyl]-, (3R)- (9CI)

Chemical Property of Piperazine, 3-ethyl-1-[(4-fluorophenyl)methyl]-, (3R)- (9CI)

Chemical Property:

• PSA: 15.27000
• LogP: 2.27620

Purity/Quality:

99%+ ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Piperazine, 3-ethyl-1-[(4-fluorophenyl)methyl]-, (3R)- (9CI)

There total 1 articles about Piperazine, 3-ethyl-1-[(4-fluorophenyl)methyl]-, (3R)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(R)-3-ethyl-1-(4-fluoro-benzyl)-piperazin-2,5-dione (685535-15-3) → (R)-3-ethyl-1-(4-fluoro-benzyl)-piperazine (685535-16-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 60 ℃; for 5h;

Reference yield: 34.0%

(R)-3-ethyl-1-(4-fluoro-benzyl)-piperazine (685535-16-4) + (E)-3-(4-chloro-2-ureido-phenyl)-acrylic acid (685535-19-7) → (5-chloro-2-{(E)-3-[(R)-2-ethyl-4-(4-fluoro-benzyl)-piperazin-1-yl]-3-oxopropenyl}-phenyl)-urea (685535-18-6)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

upstream raw materials:

(R)-3-ethyl-1-(4-fluoro-benzyl)-piperazin-2,5-dione

Downstream raw materials:

(5-chloro-2-{(E)-3-[(R)-2-ethyl-4-(4-fluoro-benzyl)-piperazin-1-yl]-3-oxopropenyl}-phenyl)-urea

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