3-Benzenesulfonylquinolin-8-ylamine

Base Information

• Chemical Name: 3-Benzenesulfonylquinolin-8-ylamine
• CAS No.: 607743-08-8
• Molecular Formula: C15H12N2O2S
• Molecular Weight: 284.338
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID001296426
• Mol file: 607743-08-8.mol

Synonyms:607743-08-8;3-BENZENESULFONYLQUINOLIN-8-YLAMINE;3-(Phenylsulfonyl)quinolin-8-amine;3-(benzenesulfonyl)quinolin-8-amine;3-Benzenesulfonyl-quinolin-8-ylamine;8-Amino-3-phenylsulfonylquinoline;SCHEMBL2196445;NSGYGDABEZHUHG-UHFFFAOYSA-N;DTXSID001296426;3-(Phenylsulfonyl)-8-quinolinamine;AKOS022193564;MB07139

Chemical Property of 3-Benzenesulfonylquinolin-8-ylamine

Chemical Property:

• PSA: 81.43000
• LogP: 4.31180
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 284.06194880
• Heavy Atom Count: 20
• Complexity: 426

Purity/Quality:

99%min ^*data from raw suppliers

3-Benzenesulfonyl-quinolin-8-ylamine >97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)S(=O)(=O)C2=CN=C3C(=C2)C=CC=C3N

Technology Process of 3-Benzenesulfonylquinolin-8-ylamine

There total 7 articles about 3-Benzenesulfonylquinolin-8-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

8-nitro-3-(phenylsulfonyl)quinoline (607743-07-7) → 3-(phenylsulfonyl)quinolin-8-amine (607743-08-8)

Guidance literature:

8-nitro-3-(phenylsulfonyl)quinoline; With iron; acetic acid; at 80 ℃; for 0.583333h;

With ammonia; water; In dichloromethane;

Reference yield: 72.0%

8-nitro-3-(phenylsulfonyl)quinoline (607743-07-7) + potassium carbonate (584-08-7) → 3-(phenylsulfonyl)quinolin-8-amine (607743-08-8)

Guidance literature:

8-nitro-3-(phenylsulfonyl)quinoline; With hydrogenchloride; titanium(III) chloride; In tetrahydrofuran; water; at 35 ℃; for 0.166667h;

potassium carbonate; In tetrahydrofuran; water; pH=8.5;

Reference yield:

C17H14N2OS → 3-(phenylsulfonyl)quinolin-8-amine (607743-08-8)

Guidance literature:

Multi-step reaction with 2 steps

1: monoperoxyphthalic acid magnesium salt hexahydrate / dichloromethane; methanol / 25 - 30 °C

2: hydrogenchloride / ethanol; water / 6 h / Reflux

With hydrogenchloride; monoperoxyphthalic acid magnesium salt hexahydrate; In methanol; ethanol; dichloromethane; water;

DOI:10.14233/ajchem.2014.15904

upstream raw materials:

8-nitro-3-(phenylsulfonyl)quinoline

potassium carbonate

8-nitro-3-bromoquinoline

C₁₇H₁₄N₂O₃S

Downstream raw materials:

8-iodo-3-(phenylsulfonyl)quinoline

Lu AE₆₀₁₅₇

Refernces

• 1、 -. "QUINOLINE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE SEROTONIN 5-HT6 RECEPTOR". Page/Page column 50. . Retrieved 2009/04/25.
• 2、 -. "QUINOLINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM". Page/Page column 17-18. . Retrieved 2010/02/11.