2-Propen-1-ol,3-[(2R)-2-methyl-1,4-dioxaspiro[4.4]non-2-yl]-,(2E)-(9CI)

Base Information

Chemical Name:2-Propen-1-ol,3-[(2R)-2-methyl-1,4-dioxaspiro[4.4]non-2-yl]-,(2E)-(9CI)
CAS No.:609842-67-3
Molecular Formula:C11H18O3
Molecular Weight:198.26
Hs Code.:
Mol file:609842-67-3.mol

Synonyms:2-Propen-1-ol,3-[(2R)-2-methyl-1,4-dioxaspiro[4.4]non-2-yl]-,(2E)-(9CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Propen-1-ol,3-[(2R)-2-methyl-1,4-dioxaspiro[4.4]non-2-yl]-,(2E)-(9CI)

Chemical Property:

PSA：38.69000
LogP:1.61070

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 2-Propen-1-ol,3-[(2R)-2-methyl-1,4-dioxaspiro[4.4]non-2-yl]-,(2E)-(9CI)

There total 5 articles about 2-Propen-1-ol,3-[(2R)-2-methyl-1,4-dioxaspiro[4.4]non-2-yl]-,(2E)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 609842-66-2
methyl (R,E)-3-(2-methyl-1,4-dioxaspiro[4.4]nonan-2-yl)acrylate

: 609842-67-3
(R,E)-3-(2-methyl-1,4-dioxaspiro[4.4]nonan-2-yl)prop-2-en-1-ol

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; at -78 ℃;
DOI:10.1016/S0040-4039(03)01583-1

Reference yield:

: 931-94-2
1,1-dimethoxycyclopentane

: 609842-67-3
(R,E)-3-(2-methyl-1,4-dioxaspiro[4.4]nonan-2-yl)prop-2-en-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / Sc(OTf)3 / acetonitrile / 20 °C

2: 97 percent / NaOMe / methanol / 20 °C

3: Dess-Martin periodinane / CH₂Cl₂ / 20 °C

4: benzene / Heating

5: 94 percent / DIBAL / CH₂Cl₂ / -78 °C

With sodium methylate; diisobutylaluminium hydride; Dess-Martin periodane; scandium tris(trifluoromethanesulfonate); In methanol; dichloromethane; acetonitrile; benzene; 4: Wittig reaction;
DOI:10.1016/S0040-4039(03)01583-1

Reference yield:

: (S)-2-Methyl-1,4-dioxa-spiro[4.4]nonane-2-carbaldehyde

: 609842-67-3
(R,E)-3-(2-methyl-1,4-dioxaspiro[4.4]nonan-2-yl)prop-2-en-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: benzene / Heating

2: 94 percent / DIBAL / CH₂Cl₂ / -78 °C

With diisobutylaluminium hydride; In dichloromethane; benzene; 1: Wittig reaction;
DOI:10.1016/S0040-4039(03)01583-1