Cyclopentane, 3-ethyl-1,1-bis(methoxymethyl)-4-methyl-, (3R,4R)-rel- (9CI)

Base Information

• Chemical Name: Cyclopentane, 3-ethyl-1,1-bis(methoxymethyl)-4-methyl-, (3R,4R)-rel- (9CI)
• CAS No.: 688298-26-2
• Molecular Formula: C12H24O2
• Molecular Weight: 200.31776
• Mol file: 688298-26-2.mol

Synonyms:Cyclopentane, 3-ethyl-1,1-bis(methoxymethyl)-4-methyl-, (3R,4R)-rel- (9CI)

Chemical Property of Cyclopentane, 3-ethyl-1,1-bis(methoxymethyl)-4-methyl-, (3R,4R)-rel- (9CI)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclopentane, 3-ethyl-1,1-bis(methoxymethyl)-4-methyl-, (3R,4R)-rel- (9CI)

There total 2 articles about Cyclopentane, 3-ethyl-1,1-bis(methoxymethyl)-4-methyl-, (3R,4R)-rel- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(chloromethyl)lithium (18645-12-0) + 4,4-bis(methoxymethyl)hepta-1,6-diene → (3S,4S)-1,1-Bis-methoxymethyl-3,4-dimethyl-cyclopentane + (+/-)-(3R,4R)-3-ethyl-1,1-bis(methoxymethyl)-4-methylcyclopentane (688298-26-2)

Guidance literature:

4,4-bis(methoxymethyl)hepta-1,6-diene; With n-butyllithium; zirconocene dichloride; In tetrahydrofuran; hexane; at -78 - 20 ℃;

(chloromethyl)lithium; In tetrahydrofuran; diethyl ether; pentane; at -78 ℃; for 1h; Further stages.;

DOI:10.1016/j.tet.2003.09.056

Reference yield:

(E)-4,4-bis(methoxymethyl)octa-1,6-diene → rac-(3R,4R)-3-ethyl-1,1-bis(methoxymethyl)-4-deuteriomethylcyclopentane + rac-(3R,4R)-3-(1-deuterioethyl)-1,1-bis(methoxymethyl)-4-methylcyclopentane + rac-(3R,4R)-3-(1-deuterioethyl)-1,1-bis(methoxymethyl)-4-deuteriomethylcyclopentane + (+/-)-(3R,4R)-3-ethyl-1,1-bis(methoxymethyl)-4-methylcyclopentane (688298-26-2)

Guidance literature:

(E)-4,4-bis(methoxymethyl)octa-1,6-diene; With n-butyllithium; zirconocene dichloride; In tetrahydrofuran; hexane; at -78 - 20 ℃;

With d⁽⁴⁾-methanol; In tetrahydrofuran; hexane; at 20 ℃; for 1h;

With sodium hydrogencarbonate; In tetrahydrofuran; methanol; hexane; at 20 ℃; for 16h; Further stages. Title compound not separated from byproducts.;

DOI:10.1016/j.tet.2007.08.105

upstream raw materials:

(chloromethyl)lithium

Refernces

• 1、 Thomas, Emma,Dixon, Sally,Whitby, Richard J.. "The regiochemistry of zirconacycle elaboration". . p. 11686 - 11701. Retrieved 2008/03/14.