PREGNENOLONE-17ALPHA,21,21,21-D4

Base Information

• Chemical Name: PREGNENOLONE-17ALPHA,21,21,21-D4
• CAS No.: 61574-54-7
• Molecular Formula: C21H28D4O2
• Molecular Weight: 320.452
• Mol file: 61574-54-7.mol

Synonyms:PREGNENOLONE-17ALPHA,21,21,21-D4;Pregnenolone-17α,21,21,21-D4

Chemical Property of PREGNENOLONE-17ALPHA,21,21,21-D4

Chemical Property:

• PSA: 37.30000
• LogP: 4.51530
• Storage Temp.: Refrigerator, Under inert atmosphere
• Solubility.: Chloroform (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly, Heated

Purity/Quality:

98% ^*data from raw suppliers

Pregnenolone-d4 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Pregnenolone-d4, is the labeled analogue of the Pregnenolone (P712200), which is a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens.

Technology Process of PREGNENOLONE-17ALPHA,21,21,21-D4

There total 10 articles about PREGNENOLONE-17ALPHA,21,21,21-D4 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

Pregnenolone (145-13-1) → pregnenolone-17α,21,21,21-d4 (61574-54-7)

Guidance literature:

With d⁽⁴⁾-methanol; prenyl bromide; at 28 ℃; for 16h;

DOI:10.1039/d1ob01275d

Reference yield:

17,21,21,21-d4-20R,22R-dihydroxycholesterol → pregnenolone-17α,21,21,21-d4 (61574-54-7)

Guidance literature:

With human P₄₅₀ 11A₁; oxygen; yeast alcohol dehydrogenase; In aq. phosphate buffer; at 37 ℃; Microbiological reaction;

DOI:10.1021/jacs.6b04437

Reference yield:

pregnenolone (145-13-1) → Pregnenolone-17α,21,21,21-d4 (61574-54-7)

Guidance literature:

With water-d2; phenyllithium; In ethyl [2]alcohol; benzene; for 0.5h; Heating;

DOI:10.1021/jo00322a022

upstream raw materials:

pregnenolone

deuteromethanol

Pregnenolone

3β-t-butyldimethylsilyloxy-pregn-5-en-20-one

Downstream raw materials:

d⁽³⁾-acetic acid

dehydroepiandrosterone

Refernces

• 1、 Nolin,Jones. "-". . p. 727,730. Retrieved 1952.
• 2、 Yoshimoto, Francis K.,Jung, I-Ji,Goyal, Sandeep,Gonzalez, Eric,Guengerich, F. Peter. "Isotope-Labeling Studies Support the Electrophilic Compound i Iron Active Species, FeO3+, for the Carbon-Carbon Bond Cleavage Reaction of the Cholesterol Side-Chain Cleavage Enzyme, Cytochrome P450 11A1". . p. 12124 - 12141. Retrieved 2016/10/03.