4-METHYL-3-NITROBENZYLAMINE

Base Information

• Chemical Name: 4-METHYL-3-NITROBENZYLAMINE
• CAS No.: 623155-53-3
• Molecular Formula: C8H10N2O2
• Molecular Weight: 166.18
• Hs Code.: 2921499090
• Mol file: 623155-53-3.mol

Synonyms:4-METHYL-3-NITROBENZYLAMINE;RARECHEM AL BW 2175

Chemical Property of 4-METHYL-3-NITROBENZYLAMINE

Chemical Property:

• Vapor Pressure: 0.00111mmHg at 25°C
• Refractive Index: 1.584
• Boiling Point: 300.7°C at 760 mmHg
• Flash Point: 135.6°C
• PSA: 71.84000
• Density: 1.208g/cm³
• LogP: 2.58540
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%Min ^*data from raw suppliers

(4-Methyl-3-nitrophenyl)methanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-METHYL-3-NITROBENZYLAMINE

There total 5 articles about 4-METHYL-3-NITROBENZYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(4-methyl-3-nitrobenzyl)isoindoline-1,3-dione (101207-48-1) → 4-methyl-3-nitro-benzylamine (623155-53-3)

Guidance literature:

With hydrazine; In ethanol; at 60 ℃; for 8h;

Reference yield:

4-methyl-3-nitrobenzyl chloride (84540-59-0) → 4-methyl-3-nitro-benzylamine (623155-53-3)

Guidance literature:

Multi-step reaction with 2 steps

1: tetra-(n-butyl)ammonium iodide; potassium carbonate / N,N-dimethyl-formamide / 4 h

2: hydrazine / ethanol / 8 h / 60 °C

With tetra-(n-butyl)ammonium iodide; potassium carbonate; hydrazine; In ethanol; N,N-dimethyl-formamide;

Reference yield:

N-(4-methyl-3-nitro-benzyl)-benzamide → 4-methyl-3-nitro-benzylamine (623155-53-3)

Guidance literature:

With hydrogenchloride;

DOI:10.1248/cpb.12.440

upstream raw materials:

1-methyl-2-nitrobenzene

2-(4-methyl-3-nitrobenzyl)isoindoline-1,3-dione

4-methyl-3-nitrobenzyl chloride

Downstream raw materials:

C₁₁H₁₄N₂O₄

C₁₁H₁₆N₂O₂

Refernces

• 1、 SEKIYA,YANAIHARA,TANAKA,SAITO. "REACTION OF AMIDE HOMOLOGS. XI. BENZAMIDOMETHYLATION OF AROMATIC". . p. 440 - 444. Retrieved 2007/10/06.