4-TERT-BUTYL-PHENYL-HYDRAZINE

Base Information

• Chemical Name: 4-TERT-BUTYL-PHENYL-HYDRAZINE
• CAS No.: 61765-93-3
• Molecular Formula: C10H16N2
• Molecular Weight: 164.25
• Hs Code.: 2928000090
• Mol file: 61765-93-3.mol

Synonyms:4-TERT-BUTYL-PHENYL-HYDRAZINE

Chemical Property of 4-TERT-BUTYL-PHENYL-HYDRAZINE

Chemical Property:

• Boiling Point: 272.4±19.0 °C(Predicted)
• PKA: 5.35±0.20(Predicted)
• PSA: 38.05000
• Density: 1.009±0.06 g/cm3(Predicted)
• LogP: 3.04300

Purity/Quality:

98%Min ^*data from raw suppliers

(4-tert-butylphenyl)hydrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-TERT-BUTYL-PHENYL-HYDRAZINE

There total 5 articles about 4-TERT-BUTYL-PHENYL-HYDRAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromo-4-tert-butylbenzene (3972-65-4) → p-tert-butylphenylhydrazine (61765-93-3)

Guidance literature:

1-bromo-4-tert-butylbenzene; With t-butoxycarbonylhydrazine; t-BuBrettPhos; [tBuBrettPhosPd(allyl)]OTf; sodium t-butanolate; In water; at 45 ℃; for 1.5h; Inert atmosphere;

With sulfuric acid; In ethanol; water; at 90 - 95 ℃; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.0c02315

Reference yield:

4-(tert-butyl)chlorobenzene (3972-56-3) → p-tert-butylphenylhydrazine (61765-93-3)

Guidance literature:

With bis(tri-ortho-tolylphosphine)palladium⁽⁰⁾; (2R)-1-[(1R)?-?1-?[bis(1,1-?dimethylethyl)?phosphino]?ethyl]?-?2-?(dicyclohexylphosphino)?ferrocene; hydrazine hydrate; potassium hydroxide; In 1,4-dioxane; at 100 ℃; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.202011161

Reference yield:

4-tert-butylphenyltosylate (7598-28-9) → p-tert-butylphenylhydrazine (61765-93-3)

Guidance literature:

With bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; N-[2-(di(1-adamantyl)phosphino)phenyl]morpholine; hydrazine hydrate; sodium t-butanolate; In toluene; at 65 ℃; for 1h; Inert atmosphere;

DOI:10.1002/anie.201003764

upstream raw materials:

4-tert-butylphenyltosylate

1-bromo-4-tert-butylbenzene

4-(tert-butyl)chlorobenzene

4-tert-Butylaniline

Downstream raw materials:

ethyl 5-ferrocenyl-1-(4-tert-butylphenyl)-1H-pyrazole-3-carboxylate

diethyl (p-(tert-butyl)phenyl)phosphonate

Refernces

• 1、 Hosseini-Sarvari, Mona,Koohgard, Mehdi. "Visible-light-mediated phosphonylation reaction: formation of phosphonates from alkyl/arylhydrazines and trialkylphosphites using zinc phthalocyanine". supporting information. p. 5905 - 5911. Retrieved 2021/07/12.
• 2、 Lundgren, Rylan J.,Stradiotto, Mark. "Palladium-catalyzed cross-coupling of aryl chlorides and tosylates with hydrazine". supporting information; experimental part. p. 8686 - 8690. Retrieved 2011/01/08.