5-Chloro-5'-deoxy-5'-iodo-2',3'-O-isopropylidene-D-uridine

Base Information

• Chemical Name: 5-Chloro-5'-deoxy-5'-iodo-2',3'-O-isopropylidene-D-uridine
• CAS No.: 61787-10-8
• Molecular Formula: C12H14FIN2O5
• Molecular Weight: 412.15
• Mol file: 61787-10-8.mol

Synonyms:5-Chloro-5'-deoxy-5'-iodo-2',3'-O-isopropylidene-D-uridine;5’-Deoxy-5’-iodo-2’,3’-O-isopropylidene-5-fluorouridine;5'-Deoxy-5-fluoro-5'-iodo-2',3'-O-(1-methylethylidene)uridine

Chemical Property of 5-Chloro-5'-deoxy-5'-iodo-2',3'-O-isopropylidene-D-uridine

Chemical Property:

• Refractive Index: 1.624
• PSA: 82.55000
• Density: 1.887g/cm³
• LogP: 1.04250
• Solubility.: Chloroform, Dichloromethane, Methanol

Purity/Quality:

97% ^*data from raw suppliers

5’-Deoxy-5’-iodo-2’,3’-O-isopropylidene-5-fluorouridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An intermediate for the preparation of 5?Deoxy-5-fluorouridine An intermediate for the preparation of 5’-Deoxy-5-fluorouridine.

Technology Process of 5-Chloro-5'-deoxy-5'-iodo-2',3'-O-isopropylidene-D-uridine

There total 2 articles about 5-Chloro-5'-deoxy-5'-iodo-2',3'-O-isopropylidene-D-uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sodium metabisulfite + 5-fluoro-2',3'-O-isopropylidene-5'-O-(p-toluenesulfonyl)uridine (82276-89-9) → 5'-deoxy-5-fluoro-5'-iodo-2',3'-O-isopropylideneuridine (61787-10-8)

Guidance literature:

With sodium iodide; In water; ethyl acetate; acetone;

Reference yield:

→ 5'-deoxy-5-fluoro-5'-iodo-2',3'-O-isopropylideneuridine (61787-10-8)

Guidance literature:

Jodverb. 6, 50percentig. Essigs., NaNO2;

DOI:10.1021/jm00213a006

upstream raw materials:

5-fluoro-2',3'-O-isopropylidene-5'-O-(p-toluenesulfonyl)uridine

Refernces