1H-Pyrrole-2-carboxaldehyde,3-ethyl-5-ethynyl-4-methyl-(9CI)

Base Information

Chemical Name:1H-Pyrrole-2-carboxaldehyde,3-ethyl-5-ethynyl-4-methyl-(9CI)
CAS No.:623945-15-3
Molecular Formula:C10H11NO
Molecular Weight:161.2
Hs Code.:
Mol file:623945-15-3.mol

Synonyms:1H-Pyrrole-2-carboxaldehyde,3-ethyl-5-ethynyl-4-methyl-(9CI)

Suppliers and Price of 1H-Pyrrole-2-carboxaldehyde,3-ethyl-5-ethynyl-4-methyl-(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 1H-Pyrrole-2-carboxaldehyde,3-ethyl-5-ethynyl-4-methyl-(9CI)

Chemical Property:

PSA：32.86000
LogP:1.67930

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrole-2-carboxaldehyde,3-ethyl-5-ethynyl-4-methyl-(9CI)

There total 5 articles about 1H-Pyrrole-2-carboxaldehyde,3-ethyl-5-ethynyl-4-methyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 623945-16-4
2-formyl-4-methyl-3-ethyl-5-[(trimethylsilyl)ethynyl]-1H-pyrrole

: 623945-15-3
2-formyl-4-methyl-3-ethyl-5-ethynyl-1H-pyrrole

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1002/jhet.5570400424

Reference yield:

: 34549-93-4
ethyl 3-ethyl-4,5-dimethylpyrrole-2-carboxylate

: 623945-15-3
2-formyl-4-methyl-3-ethyl-5-ethynyl-1H-pyrrole

Guidance literature:: Multi-step reaction with 5 steps

1.1: 60 percent / NaBrO₃; CAN

2.1: LiOH*H₂O / tetrahydrofuran; H₂O / 4 h / Heating

2.2: 85 percent / cc. HCl / -5 °C

3.1: 70 percent / sodium acetate; iodine monochloride / acetic acid; CH₂Cl₂ / 3.33 h / 80 °C

4.1: 95 percent / diethylamine; Pd(PPh₃)2Cl₂; CuI / 1 h / 50 °C

5.1: 93 percent / Bu₄NF / tetrahydrofuran / 1 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; lithium hydroxide; sodium bromate; copper(l) iodide; ammonium cerium(IV) nitrate; tetrabutyl ammonium fluoride; sodium acetate; Iodine monochloride; diethylamine; In tetrahydrofuran; dichloromethane; water; acetic acid;
DOI:10.1002/jhet.5570400424

Reference yield:

: 32948-37-1
2-formyl-5-iodo-4-methyl-3-ethyl-1H-pyrrole

: 623945-15-3
2-formyl-4-methyl-3-ethyl-5-ethynyl-1H-pyrrole

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / diethylamine; Pd(PPh₃)2Cl₂; CuI / 1 h / 50 °C

2: 93 percent / Bu₄NF / tetrahydrofuran / 1 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; diethylamine; In tetrahydrofuran;
DOI:10.1002/jhet.5570400424