Bicyclo[4.1.0]heptan-3-ol, 7,7-dimethyl-4-methylene-, (1R,6S)- (9CI)

Base Information

• Chemical Name: Bicyclo[4.1.0]heptan-3-ol, 7,7-dimethyl-4-methylene-, (1R,6S)- (9CI)
• CAS No.: 697298-84-3
• Molecular Formula: C₁₀H₁₆O
• Molecular Weight: 152.236
• Mol file: 697298-84-3.mol

Synonyms:Bicyclo[4.1.0]heptan-3-ol, 7,7-dimethyl-4-methylene-, (1R,6S)- (9CI)

Chemical Property of Bicyclo[4.1.0]heptan-3-ol, 7,7-dimethyl-4-methylene-, (1R,6S)- (9CI)

Chemical Property:

• PSA: 20.23000
• LogP: 1.96950

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Bicyclo[4.1.0]heptan-3-ol, 7,7-dimethyl-4-methylene-, (1R,6S)- (9CI)

There total 30 articles about Bicyclo[4.1.0]heptan-3-ol, 7,7-dimethyl-4-methylene-, (1R,6S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-carene epoxide (936-91-4) → (-)-(1R,3R,6S)-4-methylene-7,7-dimethylbicyclo[4.1.0]heptan-3-ol (4017-83-8,697298-84-3)

Guidance literature:

With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; diethylaluminium chloride; In hexane; benzene; at 0 ℃; for 0.5h;

DOI:10.1021/jo00292a039

Reference yield: 96.0%

4-Nitro-benzoat von (-)-(1S:4R:6R)-4-Hydroxy-Δ3(10)-carven (4017-86-1) → (-)-(1R,3R,6S)-4-methylene-7,7-dimethylbicyclo[4.1.0]heptan-3-ol (4017-83-8,697298-84-3)

Guidance literature:

With lithium methanolate; In methanol; for 0.166667h; Heating;

Reference yield: 75.0%

(+/-)-10-phenylsulfonylcar-3-ene (116872-39-0) → (+/-)-cis-3(10)-carene-4-ol (1753-35-1,4017-83-8,22339-03-3,22626-38-6,38741-15-0,116947-41-2,116947-43-4,697298-84-3) + (+/-)-trans-3(10)-carene-4-ol (1753-35-1,4017-83-8,22339-03-3,22626-38-6,38741-15-0,116947-41-2,116947-43-4,697298-84-3)

Guidance literature:

With diethylamine; triethyl phosphite; In methanol; at 55 ℃; for 10h;

DOI:10.1007/BF01455479

upstream raw materials:

(+)-Δ³-carene

(-)-(1R,3R,6S)-4-methylene-7,7-dimethylbicyclo<4.1.0>heptan-3-ol acetate

3-carene

3-carene epoxide

Downstream raw materials:

(1S,2S)-2-Chloro-1-((1S,4R,6R)-4-methoxy-7,7-dimethyl-bicyclo[4.1.0]hept-2-en-3-yl)-cyclohexanol

(1R,2R)-2-Chloro-1-((1S,4R,6R)-4-methoxy-7,7-dimethyl-bicyclo[4.1.0]hept-2-en-3-yl)-cyclohexanol