Spiro[2.3]hexane-1-carboxylic acid, 1-amino- (9CI)

Base Information

• Chemical Name: Spiro[2.3]hexane-1-carboxylic acid, 1-amino- (9CI)
• CAS No.: 625827-37-4
• Molecular Formula: C7H11NO2
• Molecular Weight: 141.16774
• Mol file: 625827-37-4.mol

Synonyms:Spiro[2.3]hexane-1-carboxylic acid, 1-amino- (9CI)

Chemical Property of Spiro[2.3]hexane-1-carboxylic acid, 1-amino- (9CI)

Chemical Property:

• Melting Point: 281-282 °C(Solv: ethanol (64-17-5); water (7732-18-5))
• Boiling Point: 291.3±23.0 °C(Predicted)
• PKA: 2.61±0.20(Predicted)
• PSA: 0.00000
• Density: 1.32±0.1 g/cm3(Predicted)
• LogP: 0.00000

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Spiro[2.3]hexane-1-carboxylic acid, 1-amino- (9CI)

There total 2 articles about Spiro[2.3]hexane-1-carboxylic acid, 1-amino- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

1-nitro-spiro[2.3]hexane-1-carboxylic acid ethyl ester → 1-amino-spiro[2.3]hexane-1-carboxylic acid (625827-37-4)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In ethanol; at 20 ℃; for 40h;

DOI:10.1016/j.tetlet.2003.09.083

Reference yield:

methylidenecyclobutane (1120-56-5) → 1-amino-spiro[2.3]hexane-1-carboxylic acid (625827-37-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / dirhodium tetraacetate / CH₂Cl₂ / 1 h / 20 °C

2: 56 percent / ammonium formate / Pd/C / ethanol / 40 h / 20 °C

With ammonium formate; dirhodium tetraacetate; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1016/j.tetlet.2003.09.083

upstream raw materials:

methylidenecyclobutane