Hydroxylamine, O-[2-(3-methoxyphenyl)ethyl]- (9CI)

Base Information

• Chemical Name: Hydroxylamine, O-[2-(3-methoxyphenyl)ethyl]- (9CI)
• CAS No.: 630108-43-9
• Molecular Formula: C9H13NO2
• Molecular Weight: 167.20502
• Mol file: 630108-43-9.mol

Synonyms:Hydroxylamine, O-[2-(3-methoxyphenyl)ethyl]- (9CI)

Chemical Property of Hydroxylamine, O-[2-(3-methoxyphenyl)ethyl]- (9CI)

Chemical Property:

• PSA: 44.48000
• LogP: 1.82830

Purity/Quality:

ORTHO-[2-(3-METHOXY-PHENYL)-ETHYL]-HYDROXYLAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Hydroxylamine, O-[2-(3-methoxyphenyl)ethyl]- (9CI)

There total 2 articles about Hydroxylamine, O-[2-(3-methoxyphenyl)ethyl]- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-[(3-methoxyphenethyl)oxy]-1H-isoindole-1,3(2H)-dione (630108-37-1) → 1-[2-(aminooxy)ethyl]-3-methoxybenzene (630108-43-9)

Guidance literature:

With hydrazine; In ethanol; for 1h; Heating;

DOI:10.1016/S0968-0896(02)00328-0

Reference yield:

2-(3-methoxyphenyl)-ethanol (5020-41-7) → 1-[2-(aminooxy)ethyl]-3-methoxybenzene (630108-43-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 25 h / 20 °C

2: 89 percent / hydrazine / ethanol / 1 h / Heating

With triphenylphosphine; hydrazine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; 1: Mitsunobu reaction;

DOI:10.1016/S0968-0896(02)00328-0

Reference yield: 88.0%

butyryl chloride (141-75-3) + 1-[2-(aminooxy)ethyl]-3-methoxybenzene (630108-43-9) → N-[2-(3-methoxy-phenyl)-ethoxy]-butyramide

Guidance literature:

With sodium carbonate; In dichloromethane; water; at 20 ℃; for 3h;

DOI:10.1016/S0968-0896(02)00328-0

upstream raw materials:

2-[(3-methoxyphenethyl)oxy]-1H-isoindole-1,3(2H)-dione

2-(3-methoxyphenyl)-ethanol

Refernces