5-(1-hydroxyethyl)-1H-pyrrole-2-carboxylic Acid

Base Information

Chemical Name:5-(1-hydroxyethyl)-1H-pyrrole-2-carboxylic Acid
CAS No.:635313-72-3
Molecular Formula:C7H9NO3
Molecular Weight:155.15126
Hs Code.:
DSSTox Substance ID:DTXSID10445963
Mol file:635313-72-3.mol

Synonyms:5-(1-hydroxyethyl)-1H-pyrrole-2-carboxylic Acid;635313-72-3;1H-Pyrrole-2-carboxylic acid, 5-(1-hydroxyethyl)- (9CI);DTXSID10445963

Suppliers and Price of 5-(1-hydroxyethyl)-1H-pyrrole-2-carboxylic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AccelPharmtech
5-(1-hydroxyethyl)-1H-Pyrrole-2-carboxylicacid 97.00%
25G
$ 9900.00

AccelPharmtech
5-(1-hydroxyethyl)-1H-Pyrrole-2-carboxylicacid 97.00%
1G
$ 3060.00

Total 2 raw suppliers

Chemical Property of 5-(1-hydroxyethyl)-1H-pyrrole-2-carboxylic Acid

Chemical Property:

PSA：73.32000
LogP:0.76620
XLogP3:0.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:155.058243149
Heavy Atom Count:11
Complexity:160

Purity/Quality:

99% ^*data from raw suppliers

5-(1-hydroxyethyl)-1H-Pyrrole-2-carboxylicacid 97.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C1=CC=C(N1)C(=O)O)O

Technology Process of 5-(1-hydroxyethyl)-1H-pyrrole-2-carboxylic Acid

There total 3 articles about 5-(1-hydroxyethyl)-1H-pyrrole-2-carboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 635313-71-2
(R,S)-ethyl 5-(1-hydroxyethyl)-1H-pyrrole-2-carboxylate

: 635313-72-3
(R,S)-5-(1-hydroxyethyl)-1H-pyrrole-2-carboxylic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; at 40 - 50 ℃; for 24h;
DOI:10.1039/b302411c

Reference yield:

: 7126-50-3
ethyl 5-formyl-1H-pyrrole-2-carboxylate

: 635313-72-3
(R,S)-5-(1-hydroxyethyl)-1H-pyrrole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / diethyl ether; tetrahydrofuran / 5 h / -23 °C

2: 17 percent / aq. NaOH / tetrahydrofuran / 24 h / 40 - 50 °C

With sodium hydroxide; In tetrahydrofuran; diethyl ether;
DOI:10.1039/b302411c

Reference yield:

: 2199-43-1
ethyl 1H-pyrrole-2-carboxylate

: 635313-72-3
(R,S)-5-(1-hydroxyethyl)-1H-pyrrole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 61 percent / POCl₃ / 1,2-dichloro-ethane / 0.25 h / Heating

2: 95 percent / diethyl ether; tetrahydrofuran / 5 h / -23 °C

3: 17 percent / aq. NaOH / tetrahydrofuran / 24 h / 40 - 50 °C

With sodium hydroxide; trichlorophosphate; In tetrahydrofuran; diethyl ether; 1,2-dichloro-ethane;
DOI:10.1039/b302411c