Leukotriene C-2

Base Information

Chemical Name:Leukotriene C-2
CAS No.:74841-69-3
Molecular Formula:C₃₀H₄₇N₃O₉S
Molecular Weight:625.784
Hs Code.:
Mol file:74841-69-3.mol

Synonyms:11-trans leukotriene;5(S)-hydroxy-6(R)-S-glutathionyl-7,9,11-trans-14-cis-eicosatetraenoic acid;leukotriene C-2

Suppliers and Price of Leukotriene C-2

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
11-transLeukotrieneC4
25μg
$ 155.00

Cayman Chemical
11-trans Leukotriene C4 ≥97%
100μg
$ 522.00

Cayman Chemical
11-trans Leukotriene C4 ≥97%
50μg
$ 276.00

Cayman Chemical
11-trans Leukotriene C4 ≥97%
25μg
$ 146.00

AHH
5S-Hydroxy-6R-(S-glutathionyl)-7E,9E,11E,14Z-eicosatetraenoicacid 97%
0.00025g
$ 888.00

Total 1 raw suppliers

Chemical Property of Leukotriene C-2

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:974.3°C at 760 mmHg
Flash Point:543.1°C
Density:1.225g/cm³
XLogP3:-1.9
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:24
Exact Mass:625.30330126
Heavy Atom Count:43
Complexity:997

Purity/Quality:

≥97% ^*data from raw suppliers

11-transLeukotrieneC4 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCC=CCC=CC=CC=CC(C(CCCC(=O)O)O)SCC(C(=O)N(CC(=O)O)C(=O)CCC(C(=O)O)N)N
Isomeric SMILES:CCCCC/C=C\C/C=C/C=C/C=C/C([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)N(CC(=O)O)C(=O)CC[C@@H](C(=O)O)N)N
Uses 11-trans Leukotriene C4 is a C-11 double bond isomer of LTC4.

Technology Process of Leukotriene C-2

There total 67 articles about Leukotriene C-2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 73958-10-8
Leukotriene C₄ methyl ester

: 73466-14-5,74841-69-3,76738-45-9,79026-71-4,79026-72-5,80629-45-4,82468-64-2,84823-19-8,84823-20-1,87391-79-5,92009-30-8,92418-31-0,92418-46-7,72025-60-6
(7E,9E,11Z,14Z)-(5S,6R)-6-[(R)-2-((S)-4-Amino-4-carboxy-butyrylamino)-2-(carboxymethyl-carbamoyl)-ethylsulfanyl]-5-hydroxy-icosa-7,9,11,14-tetraenoic acid

Guidance literature:: With potassium carbonate; In methanol; water; at 20 ℃; for 3.5h;
DOI:10.1002/1099-0690(200009)2000:17<2991::AID-EJOC2991>3.0.CO;2-H

Reference yield:

: 55797-81-4,105453-39-2
C₂₆H₂₂O₈

: 72025-60-6,73466-14-5,74841-69-3,76738-45-9,79026-71-4,79026-72-5,80629-45-4,82468-64-2,84823-19-8,84823-20-1,87391-79-5,92009-30-8,92418-31-0,92418-46-7
leukotriene C1

Guidance literature:: Multi-step reaction with 12 steps

1: 96 percent / benzoic acid / 1,2-dimethoxy-ethane / 4 h / Heating

2: 100 percent / H₂SO₄ / 3 h / 23 °C

3: 93 percent / 95percent zinc amalgam, dry hydrogen chloride / diethyl ether / 6 h / 15 °C

4: 100 percent / H₂ / 10percent Pd/C / methanol / 23 °C

5: 99 percent / dry hydroden chloride / 72 h / 23 °C

6: 98 percent / pyridine / 1.) 23 deg C, 6 h, 2.) 50 deg C, 3h

7: 98 percent / K₂CO₃ / methanol / 2 h / 23 °C

8: 96 percent / Collins reagent / CH₂Cl₂ / 0.25 h / 23 °C

9: 46 percent / 1.) s-BuLi, 3.) phosphate buffer / diethyl ether / 1.) - 78 deg C, 45 min, 2.) -110 deg C, 15 min; -78 deg C, 30 min

10: 1.) hexamethylphosphoric amide / 1.) THF, -60 deg C, 10 s, 2.) -95 deg C, 20 min

11: Et₃N / methanol / 4 h / 23 °C

12: K₂CO₃ / methanol; H₂O / 3 h / 23 °C

With pyridine; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; amalgamated zinc; phosphate buffer; Collins oxidation agent; sulfuric acid; hydrogen; sec.-butyllithium; potassium carbonate; triethylamine; benzoic acid; palladium on activated charcoal; In methanol; 1,2-dimethoxyethane; diethyl ether; dichloromethane; water;
DOI:10.1021/ja00524a045

Reference yield:

: 73957-95-6,74006-65-8
C₃₂H₃₀O₁₀

: 72025-60-6,73466-14-5,74841-69-3,76738-45-9,79026-71-4,79026-72-5,80629-45-4,82468-64-2,84823-19-8,84823-20-1,87391-79-5,92009-30-8,92418-31-0,92418-46-7
leukotriene C1

Guidance literature:: Multi-step reaction with 10 steps

1: 93 percent / 95percent zinc amalgam, dry hydrogen chloride / diethyl ether / 6 h / 15 °C

2: 100 percent / H₂ / 10percent Pd/C / methanol / 23 °C

3: 99 percent / dry hydroden chloride / 72 h / 23 °C

4: 98 percent / pyridine / 1.) 23 deg C, 6 h, 2.) 50 deg C, 3h

5: 98 percent / K₂CO₃ / methanol / 2 h / 23 °C

6: 96 percent / Collins reagent / CH₂Cl₂ / 0.25 h / 23 °C

7: 46 percent / 1.) s-BuLi, 3.) phosphate buffer / diethyl ether / 1.) - 78 deg C, 45 min, 2.) -110 deg C, 15 min; -78 deg C, 30 min

8: 1.) hexamethylphosphoric amide / 1.) THF, -60 deg C, 10 s, 2.) -95 deg C, 20 min

9: Et₃N / methanol / 4 h / 23 °C

10: K₂CO₃ / methanol; H₂O / 3 h / 23 °C

With pyridine; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; amalgamated zinc; phosphate buffer; Collins oxidation agent; hydrogen; sec.-butyllithium; potassium carbonate; triethylamine; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane; water;
DOI:10.1021/ja00524a045