3-(5-Bromopyridin-3-yl)prop-2-enoic acid

Base Information

Chemical Name:3-(5-Bromopyridin-3-yl)prop-2-enoic acid
CAS No.:638220-12-9
Molecular Formula:C₈H₆BrNO₂
Molecular Weight:228.045
Hs Code.:2933399090
DSSTox Substance ID:DTXSID10382809
Mol file:638220-12-9.mol

Synonyms:638220-12-9;3-(5-Bromopyridin-3-yl)prop-2-enoic acid;SCHEMBL746816;DTXSID10382809;PSCWUGHUOHMPAK-UHFFFAOYSA-N;3-(5-bromo-3-pyridyl)propenoic acid;3-(5-bromo-pyridin-3-yl)-acrylic acid

Suppliers and Price of 3-(5-Bromopyridin-3-yl)prop-2-enoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
3-(3-BROMOPYRID-5-YL)-PROPENOIC ACID 95.00%
10G
$ 4498.73

American Custom Chemicals Corporation
3-(3-BROMOPYRID-5-YL)-PROPENOIC ACID 95.00%
5G
$ 3054.98

Total 4 raw suppliers

Chemical Property of 3-(5-Bromopyridin-3-yl)prop-2-enoic acid

Chemical Property:

PSA：50.19000
LogP:1.94190
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:226.95819
Heavy Atom Count:12
Complexity:194

Purity/Quality:

97% ^*data from raw suppliers

3-(3-BROMOPYRID-5-YL)-PROPENOIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C=NC=C1Br)C=CC(=O)O

Technology Process of 3-(5-Bromopyridin-3-yl)prop-2-enoic acid

There total 2 articles about 3-(5-Bromopyridin-3-yl)prop-2-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 113118-81-3
5-bromopyridine-3-carbaldehyde

: 141-82-2
malonic acid

: 638220-12-9
3-(5-bromopyridin-3-yl)acrylic acid

Guidance literature:: With piperidine; pyridine; at 100 ℃; for 1h;

Reference yield:

: 638220-12-9
3-(5-bromopyridin-3-yl)acrylic acid

Guidance literature:

Reference yield:

: 638220-12-9
3-(5-bromopyridin-3-yl)acrylic acid

: 5-(3-bromopyridin-5-yl)-1-(2,4-difluorophenyl)-3-pentafluoroethyl-4,5-dihydro-1H-pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / 2 h / 100 °C

2.1: pyridine / dichloromethane / 3 h / 0 - 20 °C

3.1: methyllithium; lithium bromide / diethyl ether / 0.33 h / -78 °C / Inert atmosphere

3.2: 2 h / -78 - 20 °C / Inert atmosphere

4.1: piperidine / ethanol / 18 h / 90 °C

With piperidine; pyridine; thionyl chloride; methyllithium; lithium bromide; In diethyl ether; ethanol; dichloromethane;