Ethyl 2-(2-aminothiazol-5-yl)acetate

Base Information

Chemical Name:Ethyl 2-(2-aminothiazol-5-yl)acetate
CAS No.:62557-32-8
Molecular Formula:C7H10N2O2S
Molecular Weight:186.235
Hs Code.:2934100090
European Community (EC) Number:854-936-7
DSSTox Substance ID:DTXSID70352068
Wikidata:Q72472691
ChEMBL ID:CHEMBL1575269

Synonyms:Ethyl 2-(2-aminothiazol-5-yl)acetate;62557-32-8;ethyl 2-(2-amino-1,3-thiazol-5-yl)acetate;(2-Amino-thiazol-5-yl)-acetic acid ethyl ester;ethyl (2-amino-1,3-thiazol-5-yl)acetate;Ethyl 2-Aminothiazole-5-acetate;5-Thiazoleacetic acid, 2-amino-, ethyl ester;ethyl 2-aminothiazol-5-ylacetate;MFCD01113255;2-amino-5-thiazoleacetic acid ethyl ester;ETHYL 2-(2-AMINOTHIAZOL-5-YL)ACETATE HCL;MLS000728911;SCHEMBL1829347;CHEMBL1575269;DTXSID70352068;HMS2730H07;AMY23586;ethyl (2-aminothiazol-5-yl)acetate;SC1731;STK709699;Ethyl2-(2-aminothiazol-5-yl)acetate;AKOS003403420;ethyl-2-(2-aminothiazol-5-yl)acetate;SB37992;DS-10832;SMR000307189;CS-0042605;FT-0645515;(2-Aminothiazol-5-yl)acetic acid, ethyl ester;EN300-100616;W16667;AO-081/41753960;J-520584;Z57317553;F8887-5817;ETHYL 2-(2-IMINO-2,3-DIHYDROTHIAZOL-5-YL)ACETATE

Suppliers and Price of Ethyl 2-(2-aminothiazol-5-yl)acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Amino-5-thiazoleaceticAcidEthylEster
1g
$ 605.00

Matrix Scientific
Ethyl 2-(2-amino-1,3-thiazol-5-yl)acetate
1g
$ 720.00

Matrix Scientific
Ethyl 2-(2-aminothiazol-5-yl)acetate hydrochloride >95%
1g
$ 908.00

Matrix Scientific
Ethyl 2-(2-aminothiazol-5-yl)acetate hydrochloride >95%
5g
$ 3535.00

Matrix Scientific
Ethyl 2-(2-amino-1,3-thiazol-5-yl)acetate
10g
$ 2430.00

Matrix Scientific
Ethyl 2-(2-amino-1,3-thiazol-5-yl)acetate
5g
$ 1530.00

J&W Pharmlab
(2-Amino-thiazol-5-yl)-aceticacidethylester 97%
5g
$ 998.00

J&W Pharmlab
(2-Amino-thiazol-5-yl)-aceticacidethylester 97%
250mg
$ 149.00

J&W Pharmlab
(2-Amino-thiazol-5-yl)-aceticacidethylester 97%
1g
$ 298.00

J&W Pharmlab
(2-Amino-thiazol-5-yl)-aceticacidethylester 97%
500mg
$ 199.00

Total 49 raw suppliers

Chemical Property of Ethyl 2-(2-aminothiazol-5-yl)acetate

Chemical Property:

Vapor Pressure:0.00036mmHg at 25°C
Melting Point:100-101 °C(Solv: benzene (71-43-2); ligroine (8032-32-4))
Refractive Index:1.575
Boiling Point:318.5 °C at 760 mmHg
PKA:4.66±0.10(Predicted)
Flash Point:146.4 °C
PSA：93.45000
Density:1.295 g/cm³
LogP:1.41210
Storage Temp.:Keep in dark place,Inert atmosphere,Room temperature
XLogP3:0.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:186.04629874
Heavy Atom Count:12
Complexity:166

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-5-thiazoleaceticAcidEthylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)CC1=CN=C(S1)N
Uses 2-Amino-5-thiazoleacetic Acid Ethyl Ester is an intermediate used to synthesize thiazoloquinazoline derivatives as potent selective aurora A and B kinase inhibitors.

Technology Process of Ethyl 2-(2-aminothiazol-5-yl)acetate

There total 7 articles about Ethyl 2-(2-aminothiazol-5-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 56580-46-2
3-bromo-4-oxobutyric acid ethyl ester

: 17356-08-0
thiourea

: 62557-32-8
ethyl (2-amino-1,3-thiazole-5-yl)acetate

Guidance literature:: In ethanol; for 3h; Heating;

Reference yield:

: 56580-46-2
3-bromo-4-oxobutyric acid ethyl ester

: 62557-32-8
ethyl (2-amino-1,3-thiazole-5-yl)acetate

Guidance literature:: With ammonia; thiourea;

Reference yield:

: 14794-31-1,97900-84-0
ethyl 3-(chloroformyl)propionate

: 62557-32-8
ethyl (2-amino-1,3-thiazole-5-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; 2,6-dimethylpyridine / palladium 10% on activated carbon / 24 h / 20 °C

2: bromine / 1,4-dioxane; diethyl ether / 1.5 h / 20 °C

3: ethanol / 8 h / Reflux

With 2,6-dimethylpyridine; hydrogen; bromine; palladium 10% on activated carbon; In 1,4-dioxane; diethyl ether; ethanol;