2,6-Dichloronicotinamide

Base Information

• Chemical Name: 2,6-Dichloronicotinamide
• CAS No.: 62068-78-4
• Molecular Formula: C6H4Cl2N2O
• Molecular Weight: 191.017
• Hs Code.: 2933399090
• Mol file: 62068-78-4.mol

Synonyms:2,6-Dichloronicotinamide;2,6-Dichloropyridine-3-carboxamide

Chemical Property of 2,6-Dichloronicotinamide

Chemical Property:

• Melting Point: 148-151 °C
• Boiling Point: 315.5±42.0 °C(Predicted)
• PKA: 13.91±0.50(Predicted)
• PSA: 56.97000
• Density: 1.524±0.06 g/cm3(Predicted)
• LogP: 2.37150
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

2,6-Dichloronicotinamide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 2,6-Dichloronicotinamide

There total 5 articles about 2,6-Dichloronicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2,6-dichloropyridine-3-carboxylic acid (38496-18-3) → 2,6-dichloropyridine-3-carboxamide (62068-78-4)

Guidance literature:

2,6-dichloropyridine-3-carboxylic acid; With oxalyl dichloride; In tetrahydrofuran; N,N-dimethyl-formamide; at 15 - 25 ℃; for 8h; Inert atmosphere; Large scale;

With ammonium hydroxide; In tetrahydrofuran; at 0 - 30 ℃; for 1.5h; Large scale;

Reference yield: 73.0%

2,6-dichloro-3-pyridinecarbonitrile (40381-90-6) → 2,6-dichloropyridine-3-carboxamide (62068-78-4)

Guidance literature:

With sulfuric acid; water; at 90 ℃; for 1h;

Reference yield: 54.0%

2,6-dichloronicotinoyl chloride (58584-83-1) → 2,6-dichloropyridine-3-carboxamide (62068-78-4)

Guidance literature:

With ammonia; In 1,4-dioxane; water; at 0 ℃; for 1.25h;

DOI:10.1002/ejoc.201200978

upstream raw materials:

2,6-dichloronicotinoyl chloride

2,6-dichloro-3-pyridinecarbonitrile

2,6-dichloropyridine-3-carboxylic acid

2,6-dichloropyridine

Downstream raw materials:

2,6-dichloro-3-pyridinecarbonitrile