Technology Process of 2H-1-Benzopyran-2-carboxamide, N-[6-amino-1-(2,3-dichlorophenyl)-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-5-pyrimidinyl]-3,4-dihydro-6-hydroxy-2,5,7,8-
There total 5 articles about 2H-1-Benzopyran-2-carboxamide, N-[6-amino-1-(2,3-dichlorophenyl)-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-5-pyrimidinyl]-3,4-dihydro-6-hydroxy-2,5,7,8- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
trolox;
With
triethylamine; Diphenylphosphinic chloride;
In
ethyl acetate;
for 1h;
cooling;
5,6-diamino-1-(2,3-dichloro-phenyl)-3-methyl-1H-pyrimidine-2,4-dione;
With
triethylamine;
In
ethyl acetate;
at 20 ℃;
for 3h;
DOI:10.1016/j.bmc.2003.09.012
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: acetic anhydride / ethyl acetate / 4 h / Heating
2.1: NaOH / H2O; ethyl acetate / 6 h / 20 °C / pH 10
3.1: sodium nitrite; HCl / H2O / 2 h
4.1: H2 / Pd/C / methanol / 1 h
5.1: diphenylphosphoryl chloride; triethylamine / ethyl acetate / 1 h / cooling
5.2: 52 percent / triethylamine / ethyl acetate / 3 h / 20 °C
With
hydrogenchloride; sodium hydroxide; hydrogen; acetic anhydride; triethylamine; sodium nitrite; Diphenylphosphinic chloride;
palladium on activated charcoal;
In
methanol; water; ethyl acetate;
DOI:10.1016/j.bmc.2003.09.012
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: NaOH / H2O; ethyl acetate / 6 h / 20 °C / pH 10
2.1: sodium nitrite; HCl / H2O / 2 h
3.1: H2 / Pd/C / methanol / 1 h
4.1: diphenylphosphoryl chloride; triethylamine / ethyl acetate / 1 h / cooling
4.2: 52 percent / triethylamine / ethyl acetate / 3 h / 20 °C
With
hydrogenchloride; sodium hydroxide; hydrogen; triethylamine; sodium nitrite; Diphenylphosphinic chloride;
palladium on activated charcoal;
In
methanol; water; ethyl acetate;
DOI:10.1016/j.bmc.2003.09.012
