2-Quinoxalinamine,8-methoxy-(9CI)

Base Information

• Chemical Name: 2-Quinoxalinamine,8-methoxy-(9CI)
• CAS No.: 659729-71-2
• Molecular Formula: C₉H₉N₃O
• Molecular Weight: 175.19
• Mol file: 659729-71-2.mol

Synonyms:2-Quinoxalinamine,8-methoxy-(9CI)

Chemical Property of 2-Quinoxalinamine,8-methoxy-(9CI)

Chemical Property:

• PSA: 61.03000
• LogP: 1.80180

Purity/Quality:

99%min ^*data from raw suppliers

8-methoxy-2-Quinoxalinamine 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Quinoxalinamine,8-methoxy-(9CI)

There total 3 articles about 2-Quinoxalinamine,8-methoxy-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-chloro-8-methoxyquinoxaline (659729-70-1) → 8-methoxyquinoxalin-2-ylamine (659729-71-2)

Guidance literature:

With ammonium hydroxide; copper(l) iodide; at 140 ℃; for 0.166667h; microwave irradiation;

DOI:10.1021/jm070190p

Reference yield:

3-methoxy-benzene-1,2-diamine hydrogen sulfate → 8-methoxyquinoxalin-2-ylamine (659729-71-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 37 percent / NaHCO₃ / ethanol; H₂O; toluene / 1 h / Heating

2: 97 percent / POCl₃ / 4 h / 105 °C

3: 70 percent / CuI; aq. NH₃ / 0.17 h / 140 °C / microwave irradiation

With ammonium hydroxide; copper(l) iodide; sodium hydrogencarbonate; trichlorophosphate; In ethanol; water; toluene;

DOI:10.1021/jm070190p

Reference yield:

8-methoxy-1H-quinoxalin-2-one (659729-61-0) → 8-methoxyquinoxalin-2-ylamine (659729-71-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / POCl₃ / 4 h / 105 °C

2: 70 percent / CuI; aq. NH₃ / 0.17 h / 140 °C / microwave irradiation

With ammonium hydroxide; copper(l) iodide; trichlorophosphate;

DOI:10.1021/jm070190p

upstream raw materials:

2-chloro-8-methoxyquinoxaline

8-methoxy-1H-quinoxalin-2-one

Downstream raw materials:

3-aminoquinoxalin-5-ol

Refernces

• 1、 -. "VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS". Page/Page column 28. . Retrieved 2008/06/13.